LINEAR ASSESSMENT OF CEREBRAL AUTOREGULATION IN IDIOPATHIC PARKINSON'S DISEASE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Parkinson’s disease cases have been on the rise in the recent years, which promoted several different researches into the disorder. However, there hasn’t much research been done in the non-motor aspects of the disease. This study aims to improve the understanding of one of the non-motor symptoms of Parkinson’s disease. Specifically, this research aims to further understand cerebral autoregulation in patients with Parkinson’s disease. In order to achieve this aim, 25 subjects were recruited, with 11 healthy controls and 14 patients with Parkinson’s disease. The continuous blood pressure and continuous cerebral blood flow velocity of all subjects were recorded and processed while the subjects were at rest, tilt-up, and during hyperventilation. Linear signal and system analysis techniques were applied such as the power spectral density analysis and cross-correlation function analysis. Results showed that patients with Parkinson’s disease did not show a significant difference from the control group while at rest and after tilt-up. However, there was a significant difference between the groups during hyperventilation. The results obtained in this study suggested that the metabolic regulatory pathway for cerebral autoregulation is impaired in patients with Parkinson’s disease.
Authors and Affiliations
Chuang-chien Chiu, Ken Ying-kai Liao, Shoou-jeng Yeh
Keywords
Related Articles
- EP ID EP575975
- DOI 10.22159/ijpps.2016v8s2.15212
- Views 75
- Downloads 0
COMPARISON OF GENES EXPRESSION; MIRNA 146 A, MIR-103, MIR-423-3P, MIR-21, MIR-16 IN CELL LINES HEP-G2 SERIES 1886 AND PLC5
Objective: Detection of hepatocellular cancer cells(HCC) in vitro has reached the smallest level, that is miRNA(micro RNA) in particular miRNA146A. This study was conducted from February to May2013 at the Department of M...
QUANTITATIVE ANALYSIS OF Α-MANGOSTIN IN MANGOSTEEN (GARCINIA MANGOSTANA L.) PERICARP EXTRACT FROM FOUR DISTRICT OF WEST JAVA BY HPLC METHOD
Objective: The objective of this study was to determine the validity of analytical methods of α-mangostin using HPLC with UV detector and acidic methanol as mobile phase. Then, compare the level of α-mangostin and qual...
GC-MS ANALYSIS, HPTLC FINGERPRINT PROFILE AND DPPH FREE RADICAL SCAVENGING ASSAY OF METHANOL EXTRACT OF MARTYNIA ANNUA LINN SEEDS
Objective: To investigate the photochemical constituents present in methanol extract of martynia annua seeds using Gas Chromatography-Mass Spectroscopy(GC-MS), High-Performance Thin–Layer Chromatography(HPTLC) analysis a...
SYNTHESIS, DOCKING STUDIES AND EVALUATION OF ANTIMICROBIAL AND IN VITRO ANTIPROLIFERATIVE ACTIVITY OF 5H-CHROMENO 4,3-D PYRIMIDIN-2-AMINE DERIVATIVES
Objective: Docking studies and synthesis of 4-aryl-5H-chromeno [4,3 -d]pyrimidine-2-amine derivatives to evaluate antimicrobial and in vitro cytotoxicity activity.Methods: Docking studies were performed on Autodock Vina....
SCREENING OF ANTIOXIDANT ACTIVITIES AND THEIR BIOAVAILABILITY OF TROPICAL FRUIT BYPRODUCTS FROM INDONESIA
Objective: The objectives of this study were to investigate the antioxidant activities in peel and seed of six tropical fruits from Indonesia and to evaluate their bioavailability by in vitro digestion model.Methods: Six...