LIPID EXCHANGE BETWEEN LIPOPROTEINS OF LOW AND HIGH DENSITY TAKING INTO ACCOUNT THE OXIDATION OF LOW-DENSITY LIPOPROTEINS
Journal Title: Физика аэродисперсных систем - Year 2018, Vol 0, Issue 55
Abstract
A modified model of lipid transfer between low and high density lipoproteins (LDL and HDL) has been proposed. The modification concerns the introduction of a model for the exchange between LDL modified by the flow of radicals in the vessel wall and HDL. The influence of the flow of radicals, the lipid state of the organism and the concentration of CETP on the exchange of lipids was studied. Analysis of model calculations shows that under the conditions of the action of large radical fluxes, the transfer of cholesterol esters (CE) and triglycerides (Tg) between LDL and HDL changes its character: CE is transferred to HDL and Tg - to LDL. Such a change in the nature of the transfer may have an effect on cholesterol reverse transport (RCT).
Authors and Affiliations
S. A. Tchekatolina, V. N. Garyuk
Keywords
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- EP ID EP593821
- DOI 10.18524/0367-1631.2018.55.149871
- Views 22
- Downloads 0
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