Lipid Profile as a Marker of Pre-stage Cancer and Oral Cancer in Tobacco Users
Journal Title: International Blood Research & Reviews - Year 2015, Vol 3, Issue 1
Abstract
Aim: To investigate the serum lipid profile in conventional smokers, reverse smokers and tobacco chewers and smokers and chewers associated with precancer and oral cancer. Study Design: A cross sectional longitudinal study. Place and Duration of Study: Department of Oral medicine and Radiology, Vishnu dental college, Bhimavaram, between October 2011 and November 2013. Methodology: A total of 100 subjects with age range of 20-80 years were included and divided into five groups with 20 subjects in each group. The subjects in Group 1 were Conventional smokers, Group 2 were Reverse smokers, Group 3 were Tobacco chewers, Group 4 were Smokers and chewers and Group 5 with no habit of tobacco usage. Serum lipid profile levels were estimated and analyzed for all the five groups. Results: Total cholesterol (TC) and HDL were significantly reduced in all forms of tobacco abusers of oral precancer group. There was significant decrease of TC, HDL in conventional smokers (Group 1) and Reverse smokers (Group 2), significant decrease of total cholesterol, triglycerides, HDL, LDL, VLDL in tobacco chewers (Group 3) and smokers and chewers (Group 4) of oral cancer group compared with the controls. Total cholesterol, triglycerides, HDL, LDL, VLDL were much lower in the oral cancer group compared with the control. Although these parameters were low in the precancer group compared with the controls and triglycerides showed non –significant p value. Conclusion: An inverse relationship was obtained between serum lipid levels and oral precancer and oral cancer subjects. Thus the serum lipid profile can be used as an indicator to reflect the initial changes occurring in neoplastic cells, thus substantiating their use as a diagnostic adjuvant in monitoring the oral precancer and oral cancer condition.
Authors and Affiliations
D. Ayesha Thabusum, R. Sudhakara Reddy, T. Ramesh, N. Rajesh
Keywords
Related Articles
- EP ID EP242412
- DOI 10.9734/IBRR/2015/14140
- Views 146
- Downloads 0
Outcome of Hypertension among Diabetic Patients at Matanda Hospital in Butembo, Democratic Republic of the Congo
Background: Hypertension is the more frequent cardiovascular risk factor among diabetic patients and it amplifies the risk of other cardiovascular diseases. Aims: This survey aimed to determine factors incriminated in t...
Cytomegalovirus-induced Pure Red Cell Aplasia Successfully Treated with Ganciclovir: A Case Report
Background: Acquired pure red cell aplasia (PRCA) is a rare disease characterized by anemia, severe reticulocytopenia and absent to low bone marrow erythroid precursor cells. There are well-described associations of this...
Immunological and Hematological Profiles of Human Immunodeficiency Virus Positive Patients on Antiretroviral Treatment Followed at Institute Pasteur of Ivory Coast
Aims: The immune system and some of the organs of HIV positive patients may be subject of some disruptions caused by Anti-Retroviral Treatment (ART). This study has been initiated in order to assess the impact of ART on...
Iron Deficiency and Iron Deficiency Anemia in Adolescent Girls in Rural Upper Egypt
Background: Iron deficiency (ID) and iron deficiency anemia (IDA) in adolescents tends to increase with age due to acceleration of growth. Objectives: This study aimed to determine the prevalence of ID and IDA in adoles...
Blood Wastage Rate in a Sub-Saharan African Hospital Based Blood Bank
Background / Aims: Efforts are put into making blood safe for the recipient and non-injurious to the donor, and to avoid wastage of blood but blood is oftentimes wasted. This pilot study assessed the rate and reasons for...