Lipid Profile in Leukoplakia and Oral Cancer.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 3
Abstract
Background and objective: Abnormal lipid profiles have been associated with cancer as lipids play an important role in biological functions like cell growth and maintance of cell integrity. Various studies in the past have shown an inverse relationship between plasma lipid levels and malignancy of blood, gastrointestinal tract, lungs, brain and other head and neck carcinomas. The present study was done to evaluate the plasma lipid profile in patients with untreated oral cancer, patients with leukoplakia as compared with age and sex matched controls. Method: This study included 90 subjects among which 30 patients with oral cancer, 30 patients with leukoplakia and 30 age and sex matched subjects as controls. Plasma lipids including Total cholesterol, High density lipoprotein, Low density lipoprotein, Very low density lipoprotein, and Serum triglycerides were evaluated by enzymatic methods. Results: A decrease in total cholesterol and HDL was observed in cancer patients as well as leukoplakia (p-value of 0.195 and 0.219 respectively) as compared with controls. A significantly decreased LDL levels was observed in cancer patients (p<0.001*) as compared with patients with leukoplakia and controls. VLDL and triglycerides levels were higher in cancer and leukoplakia patients as compared with controls (p<0.011* and 0.007** respectively). TC, HDL and LDL were lower in tobacco habituates than nonhabituates. Our data also showed the evidence of inverse relationship between plasma lipid levels in oral cancer and leukoplakia. Conclusion: From our result, it was evident that an inverse relationship between plasma lipid levels and oral cancer as well as leukoplakia as seen in other malignancies. The lower levels of plasma cholesterol and other lipid constituents might be due to their increased utilization by the neoplastic cells for new membrane biogenesis. These findings strongly warrant an indepth study on alterations in plasma lipid profile in oral cancer and premalignant disorders.
Authors and Affiliations
Dr. Usha Chikkaiah
Keywords
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