Lipid Profile in Subfertile Clients with Premature Ovarian Failure: University of Ilorin Teaching Hospital Experience
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2018, Vol 7, Issue 2
Abstract
Background: Premature Ovarian Failure (POF) is associated with a higher incidence of cardiovascular events later in life. Concurrent with the ages of menopausal transition, a shift in lipid profile takes place. The increased burden may be mediated by a worsening of cardiovascular risk factors, such as lipids, corresponding with the loss of ovarian function. Aim and Objectives: To investigate serum lipid and hormonal levels in women with premature ovarian failure and compare with those of apparently healthy women of similar age. Material and Methods: The study was a cross-sectional one in which serum fasting Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels were measured in 50 women with POF and compared with 40 age matched control. Serum hormonal profiles were compared with lipid profiles and biomarkers of atherogenic index were assessed. Results:Women with POF present with statistically significant elevations in the mean values of serum FSH and LH, when compared with those of controls (p<0.001), while there were significant decrease in mean levels of serum prolactin, progesterone, testosterone and oestradiol when subjects were compared with controls (p<0.001). There were statistically significant elevations in serum total cholesterol, triglycerides, HDL-C and LDL-C, in premature ovarian failure subjects when compared with controls (p<0.001). There was statistically significantly difference when mean values of artherogenic index and Castelli ratio II of subjects were compared with those of controls. Conclusion: Loss of ovarian function at a very young age (POF) was characterized with subtle changes in the serum lipid profile (higher TC, TG, HDL-C, and LDL-C levels). It also shows that atherogenic index and Castelli ratio II are better tools for assessment of atherogenicity than CHD risk ratio and Castelli ratio I in patients with POF.
Authors and Affiliations
I. M AbdulAzeez, S. A Biliaminu, A. B Okesina, A. W. O Olatinwo, L. O Omokanye
Keywords
Related Articles
- EP ID EP280634
- DOI -
- Views 65
- Downloads 0
Coconut Water Consumption and Its Effect on Sex Hormone Concentrations
Background:Coconut water has many beneficial effects on health since it contains electrolyte, vitamins, sugar, protein, antioxidants, minerals, cytokinins and dietary fiber. Actually it is fat free and has zero cholest...
Homotypic Cell Cannibalism and Cannibalism Index-A Four Year Study in Inīltrating Ductal Carcinoma Breast
Background: Homotypic cell cannibalism is a hallmark of malignant lesions. It serves as an emerging indicator of both the anaplastic grade and invasiveness. Aim and Objectives: The present study was conducted to corr...
Large Disappearing Mullerian Cyst on Posterior Vaginal Wall: Report of a Rare Case
Cystic lesions of vagina are relatively uncommon and an incidental finding during routine gynaecological examination. Mullerian cysts are congenital cysts of vagina, usually reported during childbearing age group. Th...
Hypertrophy of Ligament of Treitz
Congenital duodenal obstruction commonly occurs due to malrotation, atresia, stenosis and annular pancreas in decreasing order of frequency. This is a case report of a 12 year old male child who presented with compla...
An Atypical Presentation of Wegener's Granulomatosis in a Child
Wegener`s granulomatosis is an autoimmune small vessel necrotising vasculitis associated with both granulomatosis and polyangiitis. While its standard form involves the upper and lower respiratory tracts and kidneys,...