Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 10
Abstract
Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid-lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabetic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. CT, TG and HDL-C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results: The results showed that CT (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL-C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ?7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ?7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.
Authors and Affiliations
Casimir D. Akpovi, Segbo A. G. Julien, Medehouenou T. C. Marc, Anago A. A. Eugenie, Akakpo B. Huguette, Frederic Loko
Keywords
Related Articles
- EP ID EP420008
- DOI 10.7439/ijbr.v6i10.2617
- Views 96
- Downloads 0
Interaction of aldose reductase and superoxide dismutase activity in liver; influence of vasopressin hormone and its modulators
The Liver is an important organ of the body for carbohydrate metabolism which include ureogenesis, glycogenolysis, gluconeogenesis. The pituitary hormone vasopressin mediates its actions on the carbohydrate metabolism th...
Cytological spectrum in patients of gastro-esophageal reflux disease: A prospective study in a tertiary care institute
Gastroesophageal reflux disease (GERD) is defined as reflux of gastric contents into mouth resulting in restrosternal burning sensation. Aims: This prospective study was undertaken with the aim to assess the cytological...
Sarcomatous lesions of Mediastinum - An unchartered territory: A tale of two case reports
Various primary and metastatic malignant lesions can occur in the mediastinumandmay cause diagnostic dilemmas in achieving definitive diagnosis. Synovial sarcoma is a malignant neoplasm predominantly affecting soft tissu...
Tissue specific differential response in metabolic activities of cerebrum, cerebellum, pons and medulla associated with thyroid dysfunction in sub-acute fluoride toxicity
Objectives: In this present in vivo study, we are trying to explore differential effects of fluoride on metabolic functions of four discrete regions of rat brain associated with thyroidal insufficiency. Methods: Male ra...
Correlation between arm span and stature in different age groups-An anthropometric study in population of Rajasthan
Background: The estimation of inter-relationship between arm span and stature has been an important tool in anthropometric measurements. It is found to be of great importance in such cases where direct measurement of sta...