Lipid Profiles in Atherosclerosis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
A study on lipoprotein oxidation and its significance for atherosclerosis: a mathematical approach. Atherosclerosis is a chronic disease which involves the buildup of cholesterol and fatty deposits within the arterial wall. This results in the narrowing of the vessel lumen, which eventually restricts blood flow to vital organs such as the heart and lungs. These events may culminate in a heart attack or stroke, the commonest causes of atherosclerosis which include the buildup of cholesterol within sub endothelial cells to form what is known as a fatty streak, the earliest identifiable evidence of atherosclerosis. Study on lipid profile levels on the second day of acute myocardial infarction; is it the right time for estimation? The main objective of this study is to note the changes that occur in the lipid profile levels following an acute myocardial ischemic attack. The lipid parameters like High density lipoprotein (HDL) had shown significant decrease and the Very low density lipoprotein (VLDL) and triglycerides (TG) had shown significant increases in cases compared to normal healthy individuals. Total cholesterol (TC) and low density lipoprotein (LDL) in cases had shown decreases compare to controls but not significant statistically. The cTnI showed a significant negative correlation with decreases in the TC and HDL and LDL. The AST showed significant negative correlation with TC and LDL only. So routine diagnosis of lipid parameter for assessing the clinical risk should be reliably assessed within 24 hours and the lipid parameters assessed after 24 hours are invalid for risk assessment for patients with AMI. Study on Atherosclerosis –an inflammatory disease. They said that atherosclerosis is an inflammatory disease. Because high plasma concentration of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal those risk factors for atherosclerosis, the process of thermogenesis has been considered by many to consist largely of the accumulation of lipid within the artery wall, Study on plasma lipoproteins, lipid transport, and atherosclerosis. They said that subjects of normal and disordered lipid metabolism were reviewed comprehensively in a multiauthor supplement to this journal in 1973 (McGowan and Walters, eds). Since that time considerable progress has been made in our understanding of the pathophysiology of plasma lipoproteins and their relationship to atherosclerosis. Two particularly notable developments have been the identification and characterization of a receptor-mediated mechanism, present in all peripheral tissues so far examined, for the uptake and catabolism of low density lipoprotein (LDL), and the recognition of the predictive power of the plasma high density lipoprotein (HDL) cholesterol concentration in relation to coronary heart disease (CHD).
Authors and Affiliations
Dr. Deepti Agnihotri, Dr. Shreya Nigoskar, Dr. Kapil Shrivastava
Keywords
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