Lipid Staus in Patients with Chronic Hepatitis C Before & After Interferon Based Therapy
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
Objective: To determine the lipid status in patients with chronic Hepatitis C before and after interferon based treatment.Method:Type of Study:- Descriptive case series.Place of Study:-Out patients department of hepatitis control program medical unit III at Liaquat University Hospital Jamshoro.Duration of Study:- 1st Feburary 2015 to 31st Jannuary 2016. Total 90 patients with chronic hepatitis C were included in this study through descriptive purposive sampling. The lipid profile was assessed pre and post treatment. Results: Of 90, 46 (51.1%) were males and 44(48.8%) were females. Pre-treatment 76 (84.4%) of patients have dyslipidemia from which, male were 44(57.8%) and female were 32(42.1%). Post treatment normal lipids were observed in 52/76 (68.4%) and the remainder 24/76 (31.5%) had insistent lipid. The pre-treatment laboratory values of cholesterol, LDL, HDL and triglycerides represented as mean±SD were 272.75±21.83, 160.44±37.93, 62.82±9.09 and 273.4±53.14 while post treatment values were 227.74±10.72, 107.62±8.53, 42.85±6.72 and 172.76±9.84 respectively. The major pre-treatment dyslipidemia was decrease in components of lipid profile such as 70% have <200mg/dl cholesterol, while ↓LDL, ↓HDL and ↓triglycerides were observed in 71.4%, 66.6% and 80% whereas significant improvement in these values were observed post treatment.Conclusion: The lipid profile can play a vital role as a treatment monitoring tool because the pre treatment laboratory values shows a significant improvement post treatment.
Authors and Affiliations
Sunil Dat Maheshwari
Keywords
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