Lipids-Risk Categories in Omani Type 2 Diabetics Impact of the National Cholesterol Educational Program
Journal Title: Sultan Qaboos University Medical Journal - Year 2006, Vol 6, Issue 2
Abstract
Objective: To evaluate the impact of the National Cholesterol Educational Program Adult Treatment Panel III (ATP III) and the Framingham Offspring Study on Omani diabetic subjects. Methods: 22 subjects with type 2 diabetes (86 females and 35 males) and 56 non-diabetic subjects (70 females and 86 males) aged 30-70 years attending Sultan Qaboos University Hospital between 999-2002 were recruited. Lipid profile, glucose, %HbAc, apoproteinA- and apoproteinB were measured. Low density lipoprotein was calculated using the Friedwald formula. ATP-III and Framingham Offspring Study guidelines were used to classify lipid parameters into coronary heart disease-risk categories. Results: Diabetic compared to non-diabetic subjects had significantly higher triglycerides of >.7 mmol/L (p=0.0) and lower low density lipoprotein cholesterol of >4.2 mmol/L (p=0.02 ) and, in female subjects only, lower high density lipoprotein cholesterol of <.5 mmo/L for ( p<0.000). In addition, 57% of diabetic subjects had abnormal aplipoproteinB of >.2 g/L compared to 49% of non-diabetic subjects. Combined raised levels of triglycerides, apolipoproteinB and low levels of high density lipoprotein were found in 42% of diabetic compared to 26% of the non-diabetic subjects (p=0.05). Diabetic subjects had significantly higher (p=0.008) NCEP risk-score for coronary artery disease, however, only 34% conformed to a NCEP 0-year-risk score of >0%. Conclusion: A substantial proportion of the Omani diabetic subjects were dyslipidaemic according to the ATP III guidelines. Tis study recommends the implementation of a lower cut-off threshold for starting lipid-modifying agents for Omani diabetics when using the 0-year Framingham Risk Scoring equation.
Authors and Affiliations
Ali I Al-Bahrani| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman, Riad Bayoumi| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman, Said A Al-Yahyaee| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman
Keywords
Related Articles
- EP ID EP13687
- DOI -
- Views 371
- Downloads 17
Cost Comparison between Laparoscopic and Open Appendectomies in Children
Objectives: Laparoscopic appendectomy (LA) for children has become very popular and is routinely performed in most health care centres around the world. Te cost of surgical procedures is always a concern for patients a...
Focal Scalp Hair Heterochromia in an Infant
Hair heterochromia involves the presence of two different non-artifcially induced colours of hair in the same individual which can be due to either iron defciency anaemia, genetic mutations or mosaicism. We report a s...
Use of Intravenous Sulprostone for the Termination of Pregnancy with Fetal Death in Second and Early Tird Trimester of Pregnancy
To study the efficacy of intravenous sulprostone (Nalador) for the termination of pregnancy with fetal death in second and early third trimester of pregnancy. Methods: Tis is a retrospective collection and analysis of d...
: Radiation Exposure from Medical Imaging A Wake-up Call for Oman!
Successful Use of Alternative Anticoagulants in the Management of Heparin-induced Thrombocytopenia with Thrombotic Complications Report of 5 cases and review of literature
Heparin is one of the most frequently used anticoagulants. It is easy to use, but can be associated with life-threatening side effects. One of these is heparin-induced thrombocytopenia syndrome (HITS), which develops...