Lipids-Risk Categories in Omani Type 2 Diabetics Impact of the National Cholesterol Educational Program
Journal Title: Sultan Qaboos University Medical Journal - Year 2006, Vol 6, Issue 2
Abstract
Objective: To evaluate the impact of the National Cholesterol Educational Program Adult Treatment Panel III (ATP III) and the Framingham Offspring Study on Omani diabetic subjects. Methods: 22 subjects with type 2 diabetes (86 females and 35 males) and 56 non-diabetic subjects (70 females and 86 males) aged 30-70 years attending Sultan Qaboos University Hospital between 999-2002 were recruited. Lipid profile, glucose, %HbAc, apoproteinA- and apoproteinB were measured. Low density lipoprotein was calculated using the Friedwald formula. ATP-III and Framingham Offspring Study guidelines were used to classify lipid parameters into coronary heart disease-risk categories. Results: Diabetic compared to non-diabetic subjects had significantly higher triglycerides of >.7 mmol/L (p=0.0) and lower low density lipoprotein cholesterol of >4.2 mmol/L (p=0.02 ) and, in female subjects only, lower high density lipoprotein cholesterol of <.5 mmo/L for ( p<0.000). In addition, 57% of diabetic subjects had abnormal aplipoproteinB of >.2 g/L compared to 49% of non-diabetic subjects. Combined raised levels of triglycerides, apolipoproteinB and low levels of high density lipoprotein were found in 42% of diabetic compared to 26% of the non-diabetic subjects (p=0.05). Diabetic subjects had significantly higher (p=0.008) NCEP risk-score for coronary artery disease, however, only 34% conformed to a NCEP 0-year-risk score of >0%. Conclusion: A substantial proportion of the Omani diabetic subjects were dyslipidaemic according to the ATP III guidelines. Tis study recommends the implementation of a lower cut-off threshold for starting lipid-modifying agents for Omani diabetics when using the 0-year Framingham Risk Scoring equation.
Authors and Affiliations
Ali I Al-Bahrani| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman, Riad Bayoumi| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman, Said A Al-Yahyaee| Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman
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