LIPOSOMAL FORMULATIONS IN CANCER THERAPY: BASIC CONCEPTS TO ADVANCED STRATEGIES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 5
Abstract
Liposomes, a phospholipid bilayer vesicular system is extensively being used and studied for drug delivery applications in cancer therapy. The reason behind is advantages that liposomes offer such as their biocompatible and non-immunogenic nature, improved bioavailability of anticancer drugs and versatility of efficiently encapsulating both hydrophilic and hydrophobic drugs. Recent advances such as surface functionalization and modifications of liposomes have played very crucial part to overcome limitations associated with conventional liposomal system which eventually has opened up many new and potential ways of cancer therapy. Surface decoration of liposomes with targeting ligand can lead to actively targeted site specific therapy of solid tumor. Recently, a number of liposomal formulations for cancer treatment are already in clinic and many are still under active research. This review discusses about the basics of liposomes such as structural, components, methods of preparation, and mainly focuses on recent advances of liposomal technology which includes various kinds of surface modification of currently used liposomes with efficient passive or active targeted drug delivery along with its mechanism, the advantages and associated drawbacks and their potential applications in treatment of cancer.
Authors and Affiliations
R. K Jani, K. M Gohil
Keywords
Related Articles
- EP ID EP622216
- DOI 10.25004/IJPSDR.2018.100505
- Views 64
- Downloads 0
PHARMACOGNOSTICAL EVALUATION AND QUALITATIVE ANALYSIS OF SACCHARUM SPONTANEUM (L.) ROOT
Saccharum spontaneum L. known as Kasa (Family: Poaceae) is a traditional herb, it has excellence medicinal value; has been advocated in the treatment gynaecological troubles, respiratory disease. Roots are used as galact...
BACTERIOLOGICAL SCREENING OF PAEDIATRIC COUGH SYRUPS MARKETED WITHIN PORT HARCOURT METROPOLIS, SOUTH-SOUTH NIGERIA
Non-adherence to good manufacturing practice alongside improper handling during dispensing, packaging and inadequate post-marketing surveillance of pharmaceutical products accounts to product’s deterioration reduced ther...
PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT ACTIVITY OF ETHIOPIAN INDIGENOUS MEDICINAL PLANTS, OCIMUM LAMIIFOLIUM HOCHST. EX BENTH AND OCIMUM BASILICUM L.
Antioxidants are the chemical substances which prevent the free radicals damage in the body. Numerous researches are going globally focussed on investigating natural antioxidants of plants origins. The aims of the presen...
EVALUATION OF MEMORY ENHANCING ACTIVITY OF LEAF EXTRACT OF DALBERGIA SISSOO IN MICE
Dalbergia sissoo (family: Fabaceae) is an Asian deciduous rosewood tree. It is the state tree of Punjab state (India) called as Shisham used for antipyretic, emesis, ulcers, leucoderma, stomach troubles and skin disease,...
DETERMINATION OF THE RUTIN, QUERCETIN AND KAEMPFEROL CONTENTS IN A GHANAIAN POLYHERBAL FORMULATION (EAF-2011) AND ITS RAW MATERIALS USING A SIMULTANEOUS RP-HPLC METHOD
Quantitative chemical fingerprinting of herbal medicines provides an avenue for addressing the challenge with their quality. In this report, chemical markers that could be labelled as active markers in the polyherbal pro...