MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME PYRAZOLE DERIVATIVES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2014, Vol 6, Issue 3
Abstract
Reaction of 3-[4-(dimethylamino)phenyl]-(1-methyl/phenyl)prop-2-en-1-one (Chalcones) was carried out with hydrazine hydrate, phenyl hydrazine, isoniazide, nicotinic hydrazide and thiosemicarbezide (corresponding hydrazides) in ethanol containing a few drops of glacial acetic acid under microwave irradiation giving N, N-dimethylaniline containing pyrazole derivatives. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1H NMR. All the synthesized compounds have been screened for their antibacterial and antifungal activities.
Authors and Affiliations
Deepak Swarnkar, Rakshit Ameta, Ritu Vyas
Keywords
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