Liver Abnormality in Carriers of Hepatitis B Virus (HBV)
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 6
Abstract
Background Viral hepatitis is a first-rate human global health problem. It is far anticipated that 40% of the world’s population has had contact with or are carriers of the hepatitis B virus (HBV). The enzymes and elements that are involved in chronic liver diseases may have a direct hepatic toxicity or may be decreased as a consequence of impaired liver function. Methods The case–control study to investigate the abnormality in the liver of carriers with HBV was conducted in Khartoum state during the period from March to April 2016. A total of 80 donors (40 male healthy control and 40 male carriers) were enrolled to investigate the abnormality of liver function by estimating the levels of T. bilirubin using vox method, direct bilirubin using vox method, albumin using bromocresol green method, AST using IFCC method, ALT using IFCC method and serum copper using atomic absorption spectrophotometer. Results The mean values of serum albumin in carriers and the control group were 4.035 g/dL ± 0.53 and 4.6175 g/dL ± 0.26, respectively. The mean values of serum copper in carriers and the control group were 0.551 mg/L ± 0.22 and 0.7003 mg/L ± 0.12, respectively. The above values were statistically significantly decreased when compared to the control group (P values 0.000). The mean values of serum T. bilirubin in carriers and the control group were 0.387 mg/dL ± 0.23 and 0.4 377 mg/dL ± 0.28, respectively. The mean values of serum direct bilirubin in carriers and the control group were 0.134 mg/dL ± 0.11 and 0.1548 mg/dL ± 0.12, respectively. The mean values of serum AST in carriers and the control group were 18.85 IU/L ± 4.02 and 22.05 IU/L ± 10.91, respectively. The mean values of serum ALT in carriers and the control group were 25.35 IU/L ± 20.91 and 21.725 IU/L ± 8.02, respectively. There were no significant differences in the mean values of bilirubin (T and D), AST and ALT when compared to control group (P values > 0.05). Conclusion The results presented in this study showed statistically significant decreases in both serum albumin and copper levels in carriers when compared to control group. There were no significant differences between the HBV carriers and control group regarding the levels of T. bilirubin, direct bilirubin, AST and ALT in our study.
Authors and Affiliations
Feroz Awadelkarim Elsayed, Omer Balla Ibrahim, Selma Ali Albashir
Keywords
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