Liver Specific Serum Micro RNA122 as a Prognostic Marker in Egyptian Patients with Liver Cirrhosis
Journal Title: Archives of Hepatitis Research - Year 2017, Vol 3, Issue 1
Abstract
Introduction: Recent research has shown that microRNAs (miRNA) are emerging as important regulators of cellular differentiation. The miR-122 accounts for approximately 70% of all miRNAs in the liver so its presence in the serum is highly indicative of liver processes. Aim of the work and methods: was to study the role of miR-122 as a prognostic new marker in patients with liver cirrhosis. MiR-122 was detected by quantitative real-time reverse transcription (RT)-PCR technique. Eighty patients with liver cirrhosis were included in our study, we divided them into 4 equal groups according to the complications of liver cirrhosis (1-compensated cirrhotics, 2- cirrhotics with ascites, 3-spontaneous bacterial peritonitis (SBP), and 4- hepatorenal syndrome (HRS) group) to evaluate if the serum level of miR-122 might be a suitable parameter for assessment of disease severity and prognosis in such patients.
Authors and Affiliations
Amin Mona A, Fawzi Mai, Sabri Dina, Sedrak Heba, Mausa Shrouk, El-Saadi Abdelaziz
Keywords
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- EP ID EP559374
- DOI 10.17352/ahr.000008
- Views 32
- Downloads 0
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