LOADING OF CLARITHROMYCIN AND PACLITAXEL ON SYNTHESIZED CdS/NiO NANOPARTICLES AS PROMISING NANOCARRIERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 5
Abstract
Objective: In this study cadmium sulfide (CdS) and nickel oxide (NiO) nanoparticles were synthesized and applied as novel nanocarriers for antibacterial drug clarithromycin (CLA) and anticancer drug paclitaxel (PTX) to improve their physical properties and biological activities.Methods: Cadmium sulfide (CdS) and nickel oxide (NiO) nanoparticles were synthesized by chemical co-precipitation and thermochemical processing techniques respectively and loaded with clarithromycin (CLA) and paclitaxel (PTX) by simple new one-step reaction. Analytical measures including FTIR, PXRD, SEM, AFM, TGA, DSC and zeta potential where used for characterization. The in vitro release, antibacterial as well as anticancer activities were evaluated.Results: Analytical measures revealed that the loading involved physical complex formation rather than chemical modification with the high percent surface loading of the drugs on the nanoparticles. Solubility/dissolution study revealed higher significant* improvement in the solubility of CLA from NiO nanoparticles than that from CdS nanoparticles while the antibacterial activity of CLA was non-significantly improved. For PTX loaded on CdS and NiO nanoparticles showed non-significant change in its solubility, but remarkable significant* increase in its antitumor activity on MCF-7 cell line accompanied with significant* reduction in its cytotoxicity on normal mammary cell line (MCF-10A) indicating the selectivity and targeting of PTX-CdS/NiO nanocarriers with reduced side effects of the drug and the used metal nanocarriers.Conclusion: This work provided most selective and safe delivery system for PTX and best method for enhancement of CLA solubility.Keywords: Clarithromycin (CLA), Paclitaxel (PTX), Cadmium sulfide (CdS) nanoparticles, Nickel oxide (NiO) nanoparticlesÂ
Authors and Affiliations
Mustafa R. Abdulbaqi, Nidhal K. Maraie, Ashour H. Dawood
Keywords
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