Locally Applied FK506 Improves Functional Recovery in Rats after Sciatic Nerve Transection
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 6
Abstract
Peripheral nerve injury (PNI) is a serious health concern for society and often causes long lasting disability. Nerve tubulization is recommended when there is too much tension for end-to-end coaptation and the gap between stumps is shorter than 3 cm. The immunosuppressive drug FK506 (Tacrolimus) has demonstrated neuroprotective and neurotrophic actions in experimental models by increasing neurite elongation and accelerating the rate of nerve regeneration in vitro and in vivo. The aim of this study was to evaluate functional recovery through walking track analysis after nerve transection with loss of substance. FK506 was used as a neurotrophic factor to stimulate neuronal growth through the tubulization technique along with a controlled drug delivery system, the alzet osmotic minipumps. Rats (n=36) were randomly assigned to three groups. Group I served as untreated controls. Groups II and III received 0.1 mg/kg/d of FK506 systemically and locally, respectively. After 90 days postoperative results showed the Group III achieved the best functional recovery (highest Sciatic Functional Index – SFI) in comparison with Groups I and II.
Authors and Affiliations
Eduardo Goldani, Marco Antônio Smiderle Gelain, Thomaz Monteiro Cardoso, Alice Cardoso Pellizzari, Mariana Dias Curra, Thaís Mariel Andara Beuren, Juliana Oliveira Rangel, Jefferson Braga Silva
Keywords
Related Articles
- EP ID EP192150
- DOI -
- Views 50
- Downloads 0
MAURIAC SYNDROME WITH CELIAC DISEASE: RARE ASSOCIATION
Growth failure in type 1 Diabetes Mellitus can occur for several reasons. Mauriac syndrome is a rare cause of severe growth failure in type 1 Diabetes Mellitus.The classical severe presentation of Celiac Disease rarely o...
A Longitudinal Study of Resident Emotional Stability, Self-Reported Health and Perceptions of Programmatic Support
Purpose: Certain characteristics such as acceptance, planning, and humility have correlated with less burnout among resident physicians. However, less is known about residency program culture, socialization, and support....
Risk Factors of Diabetes Mellitus among Saudi Patients above 40 Years in Dahda Area
Diabetes mellitus (DM) is a syndrome of chronic hyperglycaemia due to relative insulin deficiency, resistance, or both. It affects more than 120 million people world-wide, and it is estimated that it will affect 370 mill...
Prevalence, Risk Factors, and Treatment Strategies of Polycystic Ovary Syndrome at Various Hospitals, Palakkad: A Prospective Study
Aim and Objectives: To monitor and assess the prevalence, risk factors, and treatment strategies of polycystic ovary syndrome. Materials and Methods: A prospective study was conducted in various hospitals of Palakkad fro...
Clinical presentation of Cysticercosis in Bihar
Purpose: To study the clinical presentation and treatment outcome of patients with ocular & extracocular cysticercosis in Bihar. Method: The study included 14 patients who were diagnosed as ocular or extraocular cysticer...