Long Term Consumption of High Dose Sucralose Induces Hepatic Necrosis and Fibrosis in Male Albino Rats
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 5
Abstract
Background: Sucralose is one of the most popular non-nutritive sweeteners in the market. Whoever its toxicological effect are still need further investigation Materials and Methods: Three groups of 50 rats formed of a control group and two sucralose groups that received sucralose dissolved in water for 12 weeks formed of a control group and two sucralose groups. For all, liver function tests and hepatic histopathologic examination were done. Results: There was a statistically significant difference (P <0.05) among rats’ liver function tests in different study groups, with high mean of liver enzymes (ALT, AST and ALP) levels in sucralose groups (low dose group & high dose group). Also, a statistically significant difference (P <0.0001) in rats' liver necrosis in different study groups with higher effect on liver tissues among the high dose group. There was a statistically significance difference (P <0.0001) in rats' liver fibrosis in different study groups; about 55% liver tissues of the high dose group shows Grade 2 hepatic fibrosis, 30% shows Grade 1 and about 15% no fibrosis. There was no hepatic fibrosis among control and the low dose group. Conclusion: Long term use of sucralose in male albino rats produces hepatotoxicity which is more in large doses.
Authors and Affiliations
Manar M. Bayoumi, Ghada M. El Gallad, Sherin S. Ghaleb, Hala M. El-Hanbuli
Keywords
Related Articles
- EP ID EP547574
- DOI 10.21276/ijmrp.2017.3.5.047
- Views 64
- Downloads 0
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