Long term follow up of an early oligoarthritis cohort shows that early aggressive intervention leads to drug free remission after 10 years: results from the LOTO study
Journal Title: International Journal of Clinical Rheumatology - Year 2017, Vol 12, Issue 2
Abstract
Objective: To report the long-term outcome in the long-term follow up of the Leeds Early Oligoarthritis Cohort. Methods: Cross-sectional follow up of patients who participated in two previous interventional studies. Subjects were invited to either attend for a single study visit or a telephone consults. Presence/absence of any musculoskeletal symptoms and current diagnosis was recorded. Blood tests for inflammatory markers and radiographs of SIJs or any relevant joints were performed only if clinically indicated to establish a diagnosis if persistent clinical symptoms. Results: Follow up data were available from 63.3% (n=74 patients) of the initial cohort (n=117 patients) [mean SD disease duration at presentation 11.8 ± 1.8 months; disease duration at follow up: 13 ± 3 years]. Of these 74 patients, 63.51% (n=47) had persistent arthritis since the end of the previous studies (19.5% were RF positive; 33.3% anti-CCP positive and 32.4% HLA-B27 positive). The majority (75%) had received joint steroid injections sulfasalazine on the original study protocols. Oligoarthritis was still the predominant articular pattern in 68% of the patients at follow up and over a third of patients (36.5%) were in clinical remission (4% and 17.4% RF and HLA-B27 positive respectively). Conclusion: Ten-year follow up of an early oligoarthritis cohort shows that over a third of patients attending for review are in drug free clinical remission.
Authors and Affiliations
Concepción Castillo-Gallego, Michael J Green, Sibel Z Aydin, Sharmin Nizam, Paul Emery, Helena Marzo- Ortega
Keywords
Related Articles
- EP ID EP603257
- DOI -
- Views 54
- Downloads 0
A young lady with seronegative systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. It is a multisystem disease which can involve any organ in the body. Most of the SLE cases are seropositive which depend on positive test f...
IL-17 in primary knee osteoarthritis and its relation with severity of the disease
Objective: Is to measure serum level of interleukin 17 and correlate its level with disease severity in patients with primary knee OA. Methods: Serum was collected from patients with primary knee osteoarthritis and age-...
Young girl diagnosed with chronic recurrent multi-focal osteomyelitis
Chronic Recurrent Multi-focal Osteomyelitis is a rare form of inflammatory disorder diagnosed after exclusion of malignancy, and infection. It is rare due to obscure knowledge of physicians regarding this disease and lac...
Improved clinical outcomes and physical activity in patients with rheumatoid arthritis treated with originator adalimumab in routine clinical practice
Background/Objective: We aimed at evaluating changes in habitual physical activity, disease activity and physical function following treatment with originator adalimumab (ADAORIG) in patients with Rheumatoid Arthritis (R...
Piriformis syndrome: Still unsolved issues
Piriformis Syndrome (PS) is an example of extra-spinal sciatica due to compressive neuropathy and can also be named as ‘deep gluteal syndrome’, ‘pelvic outlet syndrome’ or ‘pseudo-sciatica’. Its prevalence among Low Back...