Looking Back To Old, Forgotten Antibiotics to Treat Gram Negative Superbugs
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2017, Vol 4, Issue 8
Abstract
Antibiotic resistance has emerged as one of the greatest global health challenges to be addressed in the 21st century.The reintroduction of previously used antibiotics active against extensively drug-resistant (XDR) bacteria represents a new alternative for the control of antimicrobial resistance. A total of 100 extensively drug resistant Gram negative bacilli isolated from Clinical Microbiology laboratory.Acinetobacter was found to be the most common and highly resistant organism in this study (54%), which was isolated mostly from respiratory and pus samples.Other extensively drug resistant Gram negative bacilli isolated from Clinical samples includes Klebsiella (33%) and Pseudomonas(13%).From the 100 Extensively drug resistant gram negative bacteria, the most common respiratory pathogen Acinetobacter shows 78% sensitivity towards Minocycline followed by Klebsiella (21%). Pseudomonas shows complete resistance towards this drug.The old antibiotic Fosfomycin was active against all three species (Acinetobacter 94%, Klebsiella 100% and Pseudomonas 77%).Chloramphenicol shows less sensitivity towards Klebsiella (33%) and Acinetobacter(22%) and pseudomonas(16%).97% isolates were sensitive to polymyxins\colistin
Authors and Affiliations
Anusree Prasad
Keywords
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