LYSOSOMAL MEMBRANE AND PROTEIN STABILIZATION BY DALBERGIA SISSOO (FAMILY: FABACEAE): IN VITRO ANTI-INFLAMMATORY ACTIVITY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Plants of the genus Dalbergia are reported to be useful in the treatment of arthritis, gonorrhoea and rheumatic pains. Present study was aimed to investigate the in vitro anti-inflammatory activity of ethanol extract from Dalbergia sissoo leaves (EDS) and to support its traditional use.Methods: EDS was investigated for it's in vitro anti-inflammatory activity in human red blood cell membrane stabilization (HRBC) method and protein denaturation method. Diclofenac sodium was used as the standard drug.Results: The EDS and diclofenac sodium showed a concentration dependent stabilization toward HRBC membrane with 314.3±0.01 and 34.91±0.01 µg/ml; 50% protection, respectively. EDS and diclofenac sodium also showed dose dependent protein denaturation with IC50 values 719.9±0.04 and 428.4±0.02 µg/ml, respectively.Conclusions: EDS possessed noticeable in vitro anti-inflammatory effect against the HRBC membrane stabilization method and denaturation of albumin. Further authoritative studies are necessary to make certain the mechanisms and constituents behind its anti-inflammatory actions.Â
Authors and Affiliations
Neetu Sachan, Phool Chandra, Dilipkumar Pal
Keywords
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