Macrophages - Targets of medication in multiple sclerosis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 8
Abstract
A view that Th1/CD4 lymphocytes are responsible for inflammation in multiple sclerosis is very common. However, it was proved that destruction of the axons in the demyelination plaque correlated better with macrophages and CD4 lymphocytes activity than CD8 lymphocytes activity. Macrophages play a key role in all the multiple plaques. They are usually surrounded by lymphocytes and located around the small venous vessels. Macrophages undergo polarization that depends on the activating factors. In autoimmune disorders phenotype M1 of macrophages overbalance in acute phase of inflammation. Stimulation of PRR signaling path inducts M1 to produce inflammatory cytokine like No, ROIs that destroy the tissues, TNF-alfa, IL-beta that activate inflammatory signaling NF-kappaB, as well as IL-12 and IL-23 that induce Th1 response for antigens presented by macrophages. Cytokines with the most important one Il-17 promote inflammatory process. The latest research has pointed to a crucial role for microglia activated through TLRs in polarization of γδ T cells towards neurotoxic IL-17+ γδ T cells. We have screened a library of PubMed in order to identify M2 activating substances that could be used as the potential new medications for multiple sclerosis. Interestingly, we found one very promising recent research.
Authors and Affiliations
Dorota Jasinska and Jerzy Boczon
Keywords
Related Articles
- EP ID EP405212
- DOI -
- Views 119
- Downloads 0
BURDEN OF STROKE SURVIVORS ON CAREGIVER AND QUALITY OF LIFE
Aim: To assess level of burden and quality of life of caregivers of stroke survivors. Materials and Methods: A cross-sectional study was conducted among 120 caregivers of stroke survivors. Data were collected by demogra...
Adolescents and aids: a survey of knowledge of and attitudes towards aids in the city of semirom‚ iran in 2012-2013
Background: AIDS epidemic is currentlyin the third step of its emergence and has turned into an epidemic threatening the physical community. According to a report of WHO 68 million were infected with AIDS by December 200...
Generalized cutaneous and genital form of transmissible venereal tumor (tvt) in a mongrel dog and its therapeutic management
Canine Transmissible Venereal Tumor (TVT) is a commonly occurring contagious reproductive tumor of dogs affecting both sexes. A two years old intact male mongrel dog was brought to Teaching Veterinary Clinical Complex of...
Scholastic excellence in applied medical sciences education at newly established saudi arabian universities: effect of students’ perceived intellectual ability and inquisitiveness
Introduction: Examination of students’ beliefs about themselves, or self-theories, may provide important insight into their behaviour and these results shall contribute to the body of knowledge demonstrating the utility...
The Investigation Of The Multiple Relationships Between Meyer-Briggs Type Indicators And Career Anchors With Career Adaptability Among Personnel Of Masjid Suleiman Hospitals, Iran
This study investigated the relationships between Meyer-Briggs type indicators and career anchors with career adaptability among personnel of Masjid Suleiman hospitals. We surveyed 260 employees who were selected through...