Main Components of Liquid Biopsy are Greater than it Seems?
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 1, Issue 1
Abstract
Long time ago it was wrongly thought that tumor genes and cells are only existence in the exact tumor site. In spite of the fact of the hypothesis that circulating tumor cells (CTCs) are a fundamental prerequisite to metastasis ( first projected in the 1896 by Thomas Ashworth, an Australian pathologist, ) and the presence of cfDNA report in human plasma by Mandel and Metals in 1948, liquid biopsy were totally ignored till 1977. In 1977, researchers made the novel observation that cancer patients carried cell-free DNA in their peripheral blood which was Initial progress on further of liquid biopsy. Without a doubt, significant progress was not made until recent years with the advent of Next Generation Sequencing (NGS) technology, which significantly improved the sensitivity and specificity of ctDNA detection. Interestingly, research in this field of liquid biopsy has entered a “golden age” in which the huge potential of liquid biopsy main components including CTCs, cfDNA and exosomes make tumor diagnosis and treatment much clearer than before. Liquid biopsy tests are fast traction as a viable substitute to traditional diagnostic tests for cancer. It has the potential to facilitate detect cancer at earlier stages, present a less-expensive and less-invasive way to monitor patients throughout treatment, and can help doctors make better decisions about which drugs are the best fit for personal patients.
Authors and Affiliations
Fatemeh Khatami, Seyed Mohammad Tavangar
Keywords
Related Articles
- EP ID EP582998
- DOI 10.32474/OAJOM.2018.01.000102
- Views 99
- Downloads 0
Studies on Hybridization and Genetic Diversity in Cowpea (Vigna Unguiculata L)
Crossability of various accessions of cowpea on the basis of pollen development and fruit set was studied along with genetic diversity by SSR markers. There was a significant correlation between fruit set and percent via...
Colorectal Cancer in UAE, Implications on the Screening Program 2018
a) Colorectal cancer is the fourth (4th) common cancer in both sexes, worldwide and is the third most common cancer in men and the second in women. b) In 2012, 1.36 million cases of colorectal cancer occurred and there w...
The Potential Role of Thioctic Acid in the Attenuation of Doxorubicin Induced-Cardiotoxicity
During 1950s in Italy a soil sample was isolated and found new strains of Streptomyces peucetius bacteria from which a new antibiotic was extracted with potent effect against murine tumors, this antibiotic named daunorub...
Permissiveness Paradox in Cell Cycle Progression Towards Genome Instability and Malignant Transformation
Dimensional representation of events actively executing the cell cycle dynamics of progression in carcinogenesis allow for a paradoxical emergence of highly permissive elements in the establishment of the mitotic spindle...
Metformin Treatment Represses Vascular Endothelial Growth Factor Gene Transcription in MCF-7 Breast Cancer Cells
Background/Aim:Targeting angiogenesis preferentially in cancer is a promising approach to improve treatment efficacy and safety. The aim of this study is investigate potential upregulation of Krüppel like factor-4(KLF-4)...