Main Components of Liquid Biopsy are Greater than it Seems?
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 1, Issue 1
Abstract
Long time ago it was wrongly thought that tumor genes and cells are only existence in the exact tumor site. In spite of the fact of the hypothesis that circulating tumor cells (CTCs) are a fundamental prerequisite to metastasis ( first projected in the 1896 by Thomas Ashworth, an Australian pathologist, ) and the presence of cfDNA report in human plasma by Mandel and Metals in 1948, liquid biopsy were totally ignored till 1977. In 1977, researchers made the novel observation that cancer patients carried cell-free DNA in their peripheral blood which was Initial progress on further of liquid biopsy. Without a doubt, significant progress was not made until recent years with the advent of Next Generation Sequencing (NGS) technology, which significantly improved the sensitivity and specificity of ctDNA detection. Interestingly, research in this field of liquid biopsy has entered a “golden age” in which the huge potential of liquid biopsy main components including CTCs, cfDNA and exosomes make tumor diagnosis and treatment much clearer than before. Liquid biopsy tests are fast traction as a viable substitute to traditional diagnostic tests for cancer. It has the potential to facilitate detect cancer at earlier stages, present a less-expensive and less-invasive way to monitor patients throughout treatment, and can help doctors make better decisions about which drugs are the best fit for personal patients.
Authors and Affiliations
Fatemeh Khatami, Seyed Mohammad Tavangar
Keywords
Related Articles
- EP ID EP582998
- DOI 10.32474/OAJOM.2018.01.000102
- Views 80
- Downloads 0
Plasma Lysophasphatidic Acid Level: A Diagnostic Tool and Benchmark for Ovarian Cancer Management
In ovarian cancer there is formation of tumor cells in ovarian tissues. Lysophosphatidic acid (LPA) motivated cell proliferation, migration and endurance by acting on its cognate G-protein-coupled receptors. Lysophosphat...
Hydrogen Peroxide and Cancer
I’ll share an antidotal observation that may prove useful to cancer researchers. I studied hyper-ferritism and Ferric Chloride to see its possible link to schizophrenia. Those results are well published [1,2]. However, I...
Micro-Environmental Systems and Endothelial Cells in Cooperative Tumorigenesis Account for Potential Malignant Transformation in Neurofibromatosis Type 1 Patients
Overall tumorigenesis in neurofibromatosis type 1 patients constitutes a series of specific targeting events with a central role enacted by proliferation of fibroblasts and endothelial cells in overproduction of growth f...
Immunotherapy in Some Types of Tumors
Immunotherapy exerts its antitumor action by stimulating the response immune response of patients to cancer, unlike classic treatments, which directly attack the tumor. Previously immunotherapy was limited to patients in...
Spinal Meningioma: Pathophysiology, Diagnosis and Management
Tumors have several types that can build up in or near the spine. There are many types of spinal tumors. They can appoint the spinal cord, nerve roots or the vertebrae (bones of the spine) and pelvis. Spinal tumors have...