Malarial Acute Kidney Injury: 25 Years Experience from a Center in an Endemic Region
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 6
Abstract
Background: While malaria rarely occurs in many parts of the world, it still causes serious complications like acute kidney injury (AKI) in endemic areas and needs to be reported. Methods: This study was carried out at Sindh Institute of Urology and Transplantation, Karachi, Pakistan. From January 1990 – December 2014, 5623 patients with acute kidney injury (AKI) were registered at this institution. AKI was defined as sudden rise in creatinine or decline in urine output or both. All patients had normal sized non obstructed kidneys on ultrasonography, with no previous co morbidity. Malaria parasite was seen on blood peripheral film in all patients. Results: Among total patients with AKI, 671 (11.93%) developed AKI in association with malarial infection. Average age of patients was 33.70±16.426 (range 4-98 years) with M: F ratio of 3:1. The causes were plasmodium falciparum in 59%, vivax in 15.2%, dual infection in 3.57% and undefined species in the rest. Oligo-anuria and vomiting were the most common associated symptoms along with fever. Renal replacement therapy was required in 76.6% of patients. Complete recovery was seen in 64.82%, while 21.2% died during the acute phase of illness. Jaundice, old age, altered level of consciousness, raised total leukocyte count, oliguria, hyperkalemia and falciparum malaria were the independent risk factors associated with high mortality. Conclusion: Malaria still causes significant morbidity and mortality in our part of the world. Vivax malaria which was thought to be ‘benign’ can present with hemolysis, thrombocytopenia and kidney failure, though risk of death is 2.36 fold higher with falciparum malaria.
Authors and Affiliations
Rubina Naqvi, Fazal Akhtar, Ejaz Ahmed, Rashid Sheikh, Sajid Bhatti, Abbas Haider, Anwar Naqvi, Adib Rizvi
Keywords
Related Articles
- EP ID EP340655
- DOI 10.9734/BJMMR/2016/21471
- Views 63
- Downloads 0
Tactile Acuity among Commercial Motorcyclists in Uturu, Nigeria
Aims: To determine and compare tactile acuity of commercial motorcyclists with that of their age and sex matched controls. Study Design: Cross sectional study. Place and Duration of Study: The study was done in Uturu, a...
Comparative Analysis of Maternal and Perinatal Outcomes of Trial of Vaginal Birth and Planned Repeat Caesarean Section Following a Prior Caesarean
Background: Delivery following a previous caesarean section is associated with the fear of increased maternal and perinatal morbidity and mortality. The optimal mode of such delivery remains critical with increasing rate...
Association between Body Mass Index (BMI) and Glycemic Control in Patients with Type 2 Diabetes Mellitus Admitted in a Rural Teaching Hospital in the State of Kerala, India – A Pilot Study
Aim: To determine body mass index (BMI) of all hospitalized type 2 diabetic patients and its association with HbA1C value Study Design: Pilot cross-sectional study. Place and Duration of Study: Department of Medicine, M...
Cohort Study of Factors Contributing to Mortality Two Months after Exacerbation of COPD According to Patient Destination from Emergency Department
Background: We aimed to determine the mortality two months after exacerbation of chronic obstructive pulmonary disease (eCOPD) and to identify factors associated with mortality, comparing patients admitted to wards and t...
Correction of Skeletal Openbite Using Zygomatic Miniplates
Aims: Anterior open bite is often caused by excessive vertical development of the posterior maxilla. In such cases, it is hardly possible to establish absolute anchorage for molar intrusion by traditional orthodontic mec...