Male Fertility: Association with Ca2+ ATPase
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Background: Infertility is the inability to have pregnancy, it affects 10% to 15% of married couples worldwide. Almost 20% of infertility are attributed to male factors, and another 20% due to combined male and female factors, with almost 10-15% due to unknown cause. Investigations are usually concerned about anatomical and morphological characteristics. Few researches and clinical practices take advanced laboratory tests in account. The current study aim at elaborating the role of Ca+2 –ATPase specific activity in infertility that might help in diagnosis and treatment of infertility cases who had been previously categorized as being of unknown etiology. Materials and Subjects: Through cross sectional study design we recruited 63 volunteer married adult Saudi males who were selected randomly from two main general hospitals in Jeddah, they were categorized according to fertility into primary fertility, secondary fertility, and apparently normal who served as a control group. The fresh semen from the three groups was investigated for Ca+2 –ATPase specific activity. The laboratory findings were analyzed by ANOVA test and post hoc Tukey test. Results: The mean specific activity of Ca++ ATPase for healthy fertile males (25.1 ± 1.2 μmol Pi I min. mg protein) was significantly higher than males with primary infertility (23.4 ± 1.4 μmol Pi I min. mg protein) p<0.05, and although the healthy fertile group, which was also higher than that in males with secondary infertility (24.3 ± 1.3 μmol Pi I min. mg protein), however, this difference is not statistically significant p>0.05. Conclusion: The findings of this study help in better understanding of the etiology of unknown cases of infertility, and could be used as a basis for diagnosis and treatment of this problem.
Authors and Affiliations
Sultan A. Al Ghamdi
Keywords
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- EP ID EP537711
- DOI 10.21276/ijmrp.2018.4.2.005
- Views 73
- Downloads 0
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