MALIGNANT MIXED MULLERIAN TUMOR OF UTERUS IN A DIABETIC PATIENT - A CASE REPORT
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 46
Abstract
Uterine malignant mixed mullerian tumor (MMMT) is an uncommon carcinosarcomatous neoplasm with a highly malignant, biphasic pattern consisting of both epithelial and mesenchymal components. This paper reports the clinical, pathological and immunohistochemical features of MMMT of a diabetic patient. A 56 year-old woman presented with post- menopausal bleeding for eight months. The patient underwent Total Abdominal Hysterectomy with Bilateral Salpingo-oophorectomy (TAH&BSO) with pelvic lymph nodes dissection. In pathologic evaluation, a polypoid solid and grey white mass measuring 3.5 x 3 x 2 cm was identified. Light microscopy showed biphasic pattern of epithelial component with glandular change and sarcomatous elements of spindle cells with cartilage and bone differentiation. Immunohistochemistry was performed on formalin fixed and paraffin embedded tissue with a panel of immunohistochemical markers comprising of cytokeratin (CK), vimentin and s100. The epithelial component was reactive for CK. Vimentin, S100 positivity was seen in stromal and chondroid elements, so the diagnosis of MMMT was confirmed. CONCLUSION: There may be an association between diabetes mellitus and the development of malignant mixed mullerian tumor. Special attention should be paid when attempting to sample the endometrium of these patients
Authors and Affiliations
Gireesh Achalkar
Keywords
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- EP ID EP148756
- DOI 10.14260/jemds/1543
- Views 92
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