Malignant potential of oral lichen planus an analysis of literature over the past 20 years
Journal Title: International Journal of Applied Dental Sciences - Year 2016, Vol 2, Issue 2
Abstract
The study evaluates and compares the rate of malignant transformation in OLP and OLL and the relevance of initial diagnosis of dysplasia as reported in available literature, since 1995. Method: An electronic search of literature for retrospective and prospective studies of OLP was performed in the Pub Med MEDLINE database from 1995 to 2014. A total of 38 studies were included for the analysis. Extracted data was tabulated and analyzed. Results: A total of 16032 cases of OLP and 236 cases of OLL were reviewed from 38 articles. Of these, 243 cases of OLP and 7 cases of OLL had undergone malignant transformation. The range of malignant transformation rate from studies including OLP cases alone was 0-5.8% whereas, the range for OLL recorded was 0.65-3.2%. The average rate of malignant transformation computed from these studies was 1.25% with a mean follow-up of 1.2-19 years. Conclusion: The outcome of this study reinforces the need for a mandatory long term follow-up regimen for all cases of OLP and OLL
Authors and Affiliations
Dr. Archana Gopalakrishnan, Dr. Anita Balan, Dr. Nileena R Kumar, Dr. Haris PS, Dr. Bindu P
Keywords
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