Management of Helicobacter pylori Induced Acid Peptic Disorders: An Institutional Study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 2
Abstract
A single centre study was planned to asses incidence of Helicobacter pylori infection in a patients suffering from acid peptic disorders, in order to find out burden of disease. A section was published in Journal of Evolution of Med and Dent Sciences, 2014, Vol. 3/ Issue 32/ Page 8735-8740 (eISSN 2278-4802). Present study is continuation of our ongoing work in the field of H. pylori in this study we are emphasizing on clinical features, diagnosis, treatment and response of H. pylori infection in patients with acid peptic disorders was done in order to find out the natural history of the disease and better management plan. The objective of the study was to assess the clinical features, diagnosis, treatment and response of H. pylori infection in patients with acid peptic disorders. A total of 100 subjects, suspected clinically as cases of acid peptic disorder, were subjected to upper gastro intestinal endoscopy. Two biopsies were taken and sent for rapid urease test and histopathological examination, Patients were considered to be positive for helicobacter pylori infection, even if one out of two tests (either Histopathology or Rapid urease test) is positive. Patients diagnosed as positive were started on anti H. pylori regimen (Amoxicillin 750mg BD+ Tinidazole 500 mg BD + Omeprazole 40 mg BD) and patients with negative results are started on PPI and antacids. Reviewed after 1 week to 20 days after completion of regimen. They were reviewed for symptoms persisted/relieved. The data obtained was coded and entered in Microsoft Excel Spreadsheet. The categorical data was expressed as rates, ratios and percentages and comparison was done using chi-square test. Total of 100 subjects were studied, of which 66 were males and 34 were females. Rapid urease test was positive for H. pylori infection in 40 %( n=40) of the patients and histopathological report revealed 49% (n=49) of the patients with H. pylori infection. Based onboth the diagnostic modalities of which either one may be positive (rapid urease test or histopathological examination) the H. pyloric prevalence in acid peptic disorder patients was found to be 59%. Keywords: Helicobacter pylori, Gastritis, Endoscopy, Urease Test.
Authors and Affiliations
Chetan P. R. , Mohammed Arif, Sushilkumar B. V, Naveen P. R.
Keywords
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