Mangiferin a bioactive compound of mangifera indica l on oxidative damage and antioxidant status in n-diethylnitrosoamine induced hepatocellular carcinoma in animal model
Journal Title: Journal of Pharmaceutical and Biological Sciences - Year 2018, Vol 6, Issue 4
Abstract
Our study aims at elucidating the antioxidant efficiency of Mangiferin from Mangifera indica L for its protective effect beside NNitrosodiethylamine induced Hepatocellular carcinoma HCC in rat liver carcinogenesis Studies have shown that NNitrosodiethylamine induces lipid peroxidation and alters the antioxidant status in nontarget organisms An effort has been made to study the effect of NNitrosodiethylamine induced Hepatocellular carcinoma on biochemical parameters and ameliorating results of Mangiferin Animals were segregated to six groups Group A served as control Group B induced with 001 DEN through water for 15 weeks to induce hepatocellular carcinoma Group C received Mangiferin via intragastric intubation at a daily dose of 30 mgkg body weight for 16 weeks every day Groups D to F animals received 001 of DEN as in Group B along with Mangiferin via intragastric intubation at a daily dose of 10 20 and 30 mgkg body weight for throughout the experimental period for 4 month The study highlights the effectiveness of Mangiferin as protective molecule against NNitrosodiethylamine induced carcinoma Histological studies of liver tissue too correlated with the above biochemical findings These results clearly suggest that Mangiferin treatment prevents liver damage lipid peroxidation and protects the antioxidant defense system in DENinduced liver carcinogenesis in ratsKeywords Mangifera indica L Mangiferin NNitrosodiethylamine Antioxidants Antioxidant enzymes
Authors and Affiliations
R Maheswari, M Saranya
Keywords
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- EP ID EP512465
- DOI 10.18231/2320-1924.2018.0016
- Views 85
- Downloads 0
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