Mathematical Model of Pharmacokinetic Behavior of Orally Administered Prednisolone in Healthy Volunteers
Journal Title: Journal of Pharmaceutics & Pharmacology - Year 2014, Vol 2, Issue 2
Abstract
The objective of the current study was to develop mathematical models that described the pharmacokinetic behavior of prednisolone in healthy subjects after the oral administration of prednisolone. The current study is a companion piece of a related Leclercq and Copinsehi prednisolone study published in the February 1974 issue of the Journal of Pharmacokinetics and Biopharmaceutics. In the study cited here, plasma concentration versus time profiles of prednisolone were determined, however, no mathematical models of the pharmacokinetic behavior of prednisolone were developed. Therefore in the current study, mathematical models of the pharmacokinetic behavior of prednisolone were developed using mathematical and computational tools from the theory of dynamic systems. The current study demonstrated the successful use of mathematical and computational tools from the theory of dynamic systems in pharmacokinetic modeling.
Authors and Affiliations
Maria Durisova
Keywords
Related Articles
- EP ID EP198028
- DOI 10.13188/2327-204X.1000010
- Views 77
- Downloads 0
The Role of Protein S-Nitrosylationin Alzheimer’s Disease and its Treatment
As a post-transcriptional modification, S-nitrosylation is a covalent binding of nitric oxide to cysteine thiols in proteins to form S-nitrosothiols. Nitric oxide is recognized as an important signaling molecule, and has...
A Review of Community Pharmacy-Based Pharmacologic Interventions and Methods for Smoking Cessation
Background: The aim of this study was to provide an overview of the published peer-reviewed literature related to community pharmacy-based smoking cessation counseling efforts in the United States and Canada. Methods: E...
Preparation and Evaluation of Ibuprofen Solid Dispersion Tablets with Improved Dissolution and Less Sticking Using Porous Calcium Silicate
The aim of this study was to prepare and evaluate Ibuprofen (IBU) solid dispersion tablets with improved dissolution and less sticking using Porous Calcium Silicate (PCS). Solid dispersion granules were prepared using wa...
NMDA Receptor Antagonism by Phencyclidine Reduces NWASP and WAVE1 Protein Expression and Reduces Levels of Myelination Markers in the Prefrontal Cortex of Rats
N-methyl-D-aspartate (NMDA) receptor antagonism by perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. It is routinely used to model pathological proc...
Reactive Oxygen Species as β2-Adrenergic Receptor Signal Transducers
Reactive oxygen species (ROS), which include superoxide (O2−), hydrogen peroxide (H2O2), and the hydroxyl radical (OH.), have traditionally been cast as cellular byproducts, having benefit only for their microbicidal pro...