Genotyping and drug response: Use of single nucleotide polymorphisms (SNPs) versus haplotypes to predict albuterol efficacy

Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state

The deamidation kinetics of 7 model peptides (VYPNGA, VYGNGA, VFGNGA, VIGNGA, VGGNGA, VGPNGA, and VGYNGA) were studied at 70°C in pH 10 buffer solutions and at 70°C and 50% relative humidity in lyophilize...

Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats

Literature reports have suggested that hemodynamic response toward organic nitrates may be reduced in obese patients, but this effect has not been studied. We compared the mean arterial pressure (MAP) responses toward si...

Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans

The online version of this article (doi:10.1208/s12248-014-9636-1) contains supplementary material, which is available to authorized users.

Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

The development of therapeutic proteins requires the understanding of the relationship between the dose, exposure, efficacy, and toxicity of these molecules. Several intrinsic and extrinsic factors contribute to the chal...