A new equivalence based metric for predictive check to qualify mixed-effects models
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 3
Abstract
Authors and Affiliations
Pravin R. Jadhav, Jogarao V. S. Gobburu
Pravin R. Jadhav, Jogarao V. S. Gobburu
Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response
In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination produ...
Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist
Macitentan is a dual endothelin receptor antagonist under phase 3 investigation in pulmonary arterial hypertension. We investigated the effect of cyclosporine (Cs) and rifampin on the pharmacokinetics of macitentan and i...
Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments
Multiple outputs or measurement types are commonly gathered in biological experiments. Often, these experiments are expensive (such as clinical drug trials) or require careful design to achieve the desired information co...
A novel in vitro release method for submicron-sized dispersed systems
Sink conditions are often violated when using conventional release methods for dispersed systems. A novel reverse dialysis bag method was designed to overcome this problem. Model drug transport rates from submicron emuls...
Comparative In Silico–In Vivo Evaluation of ASGP-R Ligands for Hepatic Targeting of Curcumin Gantrez Nanoparticles
The online version of this article (doi:10.1208/s12248-013-9474-6) contains supplementary material, which is available to authorized users.