MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Simultaneous mathematical determination of rosuvastatin calcium and propranolol hydrochloride was described using different methods. The mathematical determination involves different chemometric models, namely, partial least square (PLS-1) as traditional model and artificial neural network as advanced model with and without variable selection procedure (genetic algorithm) .Experimental: A two factor, 5-level experimental design was established resulting in 25 mixtures with variable ratios of the drugs. Thirteen mixtures were used as a calibration set and the last twelve mixtures were used as a validation set to validate the ability of the prediction. Conclusion: The methods were used for quantitative analysis of the drugs in raw materials and pharmaceutical dosage form. The validity of the proposed methods was assessed using the standard addition technique.
Authors and Affiliations
ASHRAF ABDEL FATTAH, NASR M. EL-ABASAWI, KHALID A. M. ATTIA, AHMAD A. M. ABO-SERIE, SAMER MORSHEDY
Keywords
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