Matrix metalloproteinases and adamalisyns in pathomechanism of pemphigoid
Journal Title: Postępy Dermatologii i Alergologii - Year 2005, Vol 22, Issue 6
Abstract
Matrix metalloproteinases (MMPs) are members of a large family of enzymes that can degrade extracellular matrix (ECM). Matrix metalloproteinases and a specific adamalisyns participate in a broad variety of normal and pathologic states and recent evidence implicates the MMP family as potential mediators of remodeling and degradation of extracellular matrix. The abnormal regulation of MMPs and specific inhibitors of metalloproteinases (TIMPs) expression may cause destruction of tissue in some diseases. There is some evidence activity of metalloproteinases is elevated in pathogenesis of bullous diseases in which they play, perhaps, a crucial role in blisters formation.
Authors and Affiliations
Agnieszka Żebrowska, Magdalena Bogdańska, Elżbieta Waszczykowska
Keywords
Related Articles
- EP ID EP139055
- DOI -
- Views 62
- Downloads 0
Erythrasma in clinical - laboratory material of Provincial Skin and Venereal Clinic in Kielce from 1997 to 2004
The frequency of isolation of C. minutissimum at persons from Œwiętokrzyskie Province referred to laboratory examination in Micological Laboratory in WPSW in Kielce has been shown. Among 28 238 examined, the positive res...
Evaluation of functional activity of patients with chronic venous insufficiency and leg ulcer
The aim of the study was to evaluate an activity of elderly patients in aspect of everyday functionning. The influence of chronic venous insufficiency and its complications on the degree of independence of patients treat...
Alergia pokarmowa. Część II – Ryby
W pracy omówiono następujące zagadnienia: 1) epidemiologię alergii na ryby z uwzględnieniem osobliwości objawów u dzieci i dorosłych; 2) wziewną alergię na ryby; 3) skryte źródła ryb; 4) obraz kliniczny alergii na ryby;...
Food allergy. Part III - Nuts
To what extent do psoriasis patients take an interest in their condition? - a pilot study
Knowledge of psoriasis patients about their condition may have fundamental importance in effective control of the disease. Psoriasis is one of the most common diseases affecting 1.5-2.8% of our population, afflicting bot...