Mean Platelet Volume- Correlation with HbA1c and Its Association with Microvascular Complications In Type Ii Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
BACKGROUND: Diabetes mellitus (DM) is a global pandemic. Increased platelet activation has been suggested to be involved in the pathogenesis of vascular complications. Platelet volume, a marker of the platelet function and activation, is proposed to be involved as a causative factor with respect to altered platelet morphology and function. Mean platelet volume (MPV), an important, simple, effortless, and cost-effective tool and thus has potential to be used as an indicator of presence of vascular complications. AIM: The aim of the study is to compare MPV in type 2 Diabetes Mellitus patients with good glycemic control with that of poor glycemic control and to investigate the association between MPV and microvascular complications of diabetes. MATERIALS AND METHODS: This is a cross sectional study carried out on 100 cases of Type 2 Diabetes mellitus patients. Their BMI was calculated and SBP,DBP measured. Venous samples were collected after 12 hours of overnight fasting at 8:30 am for Mean Platelet Volume, HbA1C, FBS, PPBS, Hb, triglyceride (TG) and serum creatinine levels. Complications were assessed based on spot ACR and direct ophthalmoscopic examination. The patients were divided into 2 groups based on HbA1C levels and all the parameters and complications were compared between both the groups. RESULTS: Mean platelet volume is higher in diabetics with poor glycemic control (10.01-12.00 fL) than those with good glycemic control (≤ 8.00 fL). It is still higher in those with diabetic complications (10.01-12.00 fL). MPV shows a strong correlation with FBS, PPBS, HbA1c, and presence of hypertension and duration of diabetes. CONCLUSION: Our results showed significantly higher MPV in poorly controlled diabetics, and still higher in those with microalbuminuria and retinopathy. Hence, MPV can be used as an indicator of presence of microvascular complications.
Authors and Affiliations
T B Umadevi, C S Gauthaman, A Mohamed Ibrahim, K Muralidharan, A Ahamed Shafeeq
Keywords
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- EP ID EP554133
- DOI 10.9790/0853-1803031420.
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