Diabetes Disease Burden by Platelet Indices As Possible Biomarkers in Evaluation of Initial Vascular Risks in Grading Diabetes Mellitus Part I: Correlation of Platelet Dysfunction Indices With Hematopoietic and Biochemical Parameters
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Diabetes disease burden in Diabetes mellitus was explored for its possible association with hematopoietic indices and serum predictors of hypertension with dyslipidemia. Hypothesis was that disease burden of diabetes is correlated with change in serum levels of sugar, lipoproteins, urea, uric acid, creatinine and hematological parameters as consequence of platelet dysfunction manifested as dyslipidemia, nephrosis, thrombosis and diabetes mellitus. A total of 125 diabetic patients with different disease burden were analyzed for correlation and contribution of serum sugar, lipoproteins, urea, uric acid, creatinine and hematological parameters with platelet dysfunction as ‘diabetes disease burden index’. Results showed that ‘diabetes disease burden index’ may reflect the initial trigger of dyslipidemia, hypertension followed by progressive renal complications with growing risk of atherothrombosis as increased burden and uncontrolled diabetes based on comparison of P values between diabetes groups. Males in their fifties age were at high risk of diabetes. Change in serum levels of sugar, lipoproteins, urea, uric acid, creatinine as contributing factors showed ‘diabetes disease burden index’with increased risks in the order of sugar < lipids < platelet indices < urea < creatinine < hematological parameters < uric acid. Deranged platelet indices were closely associated with initial vascular complication and progressive diabetes. In conclusion, diabetes disease burden associated with platelet indices, biochemical and hematopoietic biomarkers served as better risk indicators of progressive vascular complications in diabetes mellitus patients.
Authors and Affiliations
Rajiv Kumar Ranjan, Sabiha Ashraf, Sompal Singh, Harender Beer Singh, Madhur Kudesia, Rakesh Sharma
Keywords
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- EP ID EP406713
- DOI 10.9790/0853-1710113345.
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