MEASUREMENT OF CADMIUM CONCENTRATION IN BLOOD AND FOLLICULAR FLUID TO ASSESS ITS RELATION WITH OOCYTE AND EMBRYO QUALITY IN WOMEN UNDERGOING INTRA CYTOPLASMIC SPERM INJECTION
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 10
Abstract
Background: Cadmium, is known to cause opposing reproductive effects, and classified as an endocrine disrupting chemical. Objectives: General population has relatively higher exposure to environmental pollution, the goal in this study is to assess the effect of Cadmium concentration level in blood and follicular fluid on oocyte, embryo quality and pregnancy success in women undergoing ICSI. Patient, Materials and Methods: This study included 70 infertile couples joined in assisted reproductive technology (ART) programs to enter ICSI cycle in high Institute for Infertility Diagnosis and Assisted Reproductive Technologies and Kamal AL-Samarai Hospital, center of fertility and IVF(Baghdad/Iraq) during the period from October 2016 to February 2017. The level of Cadmium concentration will be measured and assess their effect on oocyte and embryo quality. Results: highly significant difference was observed in follicular fluid cadmium (p- value 0.0429, P < 0.05) also there was No-significant difference was observed in blood cadmium(P < 0.05). Blood Cadmium in pregnant there was negatively correlated with (M1, M2, GV, rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer but in no- pregnant group there was positive correlated with (M1,M2,GV,rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer. Follicular fluid cadmium in pregnant group shows positive correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer and negative correlation with GV, rapture and M1 type of oocyte. Follicular fluid cadmium in no-pregnant there was positive correlation with GV, rapture and M1 type of oocyte and negative correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer. Conclusions: There was a Significant difference in follicular fluid cadmium between pregnant and no–pregnant. The Increasing number of oocyte lead to increase the fertilization rate, high number of embryo transfer(grade1) this lead to increase chance of pregnancy outcome.
Authors and Affiliations
Dr. Shams A. Burhan
STUDYING THE EFFECT OF SPINAL ANESTHESIA ON PLATELET FUNCTION UNDERGOING CESAREAN SECTION
In clinical practice, the only tests of platelet function are bleeding time and platelet number. Bleeding time lacks sensitivity and specificity but the PFA‐100, an in vitro analyser of platelet function may be of value....
EPIGENETICS
Epigenetics is the study of heritable changes in gene function that do not involve changes in the sequence. The Greek prefix epic- (ἐπι- "over, outside of, around") in epigenetics implies features that are "on top of" or...
A CONCEPTUAL STUDY OF PRISHTHA GATA MARMA
The term marma means pran, jiva or life. It can be explained as sandhisthanam or jeevasthanam. Marma are the meeting place of five elements of the body namely- Mamsa, Sira, Snayu, Asthi and Sandhi. These are the vital ar...
SYNTHESIS OF COUMARIN AND THEIR DERIVATIVES WITH THEIR APPLICATINS BY DIFFERENT METHODS
Coumarin is a natural product obtained from mullein (Verbascum spp.), sweet grass (Hierochloe odorata), cassia cinnamon (Cinnamomum cassia) tonka bean (Dipteryx odorata), vanilla grass (Anthoxanthum odoratum) and sweet w...
ETHNOBOTANICAL SURVEY AND PHYTOCHEMICAL STUDIES OF GUIERA SENEGALENSIS LAM. IN MUBI LOCAL GOVERNMENT OF ADAMAWA STATE
The Sudano-Sahelian species Guiera senegalensis is a small shrub found mainly in West Africa. It is well known in the Sahel, where it grows gregariously, forming abundant single-species colonies on fallow clay or sandy s...