Measurement of doxycycline in pharmaceutical Samples with SnO2 nanoparticles by spectrophotometric method
Journal Title: Journal of Research in Medical and Dental Science - Year 2017, Vol 5, Issue 3
Abstract
In this work, The SnO2 nanoparticles were characterized which developed a novel SnO2 nanoparticleassisted matrix solid-phase extraction (SnO2 -SPE) method for extraction of doxycycline from pharmaceutical and environmental samples. A simple, rapid and sensitive method termed as solid phase extraction (SPE) combined with spectrophotometric method has been proposed for the determination of trace amounts of doxycycline (DOX) in pharmaceutical samples. The influences of effective parameters on the extraction efficiency were studied. The effect of the different parameters such as pH, extraction time, effect of the salt, nanoparticle amount and extraction temperature has been studied. Under optimized condition, the method was successfully applied to the extraction of DOX from aqueous samples and relative recovery amount of 89%, detection limit of 25μg L-1 and a relative standard deviation (RSD) of 2.3% were obtained. The method linear response was over a range of 10–50000μgL−1 with R2 = 0.991. The whole procedure showed to be conveniently fast and high extraction efficiency of DOX from real samples.
Authors and Affiliations
S. Batool hosseini, Mahmoud Ebrahimi, Mohammad Reza Bozorgmehr
Keywords
Related Articles
- EP ID EP344730
- DOI -
- Views 164
- Downloads 0
Barriers and facilitators of spiritual therapy in cancer patients in Iran: A qualitative study
As a life-threatening disease, cancer requires the use of spiritual therapy. However, spiritual therapy is not sufficiently utilized for cancer patients in Iran. The present study was therefore conducted with the aim to...
A Study Showing Association between Hscrp and S. Cholesterol Level in Overweight and Obese Patients in Tertiary Care Centre In Gujarat, India
Obesity is rapidly growing health problem in both developed and developing countries. In adults, obesity is associated with hyperinsulinemia, insulin resistance, dyslipidemia, and vascular dysfunction. C - reactive prote...
The Role of Occupational Stress in Prediction of Marital Satisfaction among Married Nurses Occupied at Shahid Motahari Hospital, Jahrom
This study is aimed to explain the role of stress in prediction of marital satisfaction among married nurses occupied at Shahid Motahari Hospital, Jahrom, Iran. This research, in terms of nature and objectives, is an app...
Comparative Study of Modified Chlorhexidine Toxicity, Chlorhexidine and Sodium Hypochlorite on Gingival Fibroblast Cells L929 In Vitro
One obvious and good properties of sodium hypochlorite is capacity of tissue solubility which has effective role in direct root canal cleaning, necrotic tissues and root canal system complexity. Chlorhexidine, in spite o...
Assessment of Knowledge Regarding Rubella Infection amongst the Medical Students in a Government Medical College of Southern Rajasthan
Rubella (German measles) is a mild viral disease characterized by mild fever and rashes and is contagious by sneezing and coughing. Though it commonly affects the children but if it infects a pregnant woman, it leads to...