MECHANICAL AND RELEASE PROPERTIES OF VERNONIA GALAMENSIS TABLET FORMULATIONS PREPARED USING GELATIN AS BINDER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
The purpose of this study was to formulate the crude aqueous leaf extract of Vernonia galamensis (used in folk medicine for the treatment of diabetes mellitus) into conventional tablets using three selected efflorescent diluents namely Aerosil® 200, Avicel® PH 101 and calcium phosphate, due to the deliquescent nature of the extract. Attempted use of ordinary diluents for the tablet formulation had resulted to tablets defects. The crushing strength, friability, disintegration and dissolution times of tablets were determined using the methods specified in BP 2007. The rank order of crushing strength - friability, disintegration time ratio (CSFR:DT) and dissolution rate values using gelatin as binder in terms of the three efflorescent diluents used was; calcium phosphate > Avicel® PH 101 > Aerosil® 200. Results indicate that good quality tablets of the deliquescent crude extract of Vernonia galamensis could be produced using the three selected efflorescent diluents with gelatin as binder but tablets produced using calcium phosphate as diluent were of best quality.
Authors and Affiliations
Musa Autamashih, Adamu Isah , Teriyila Allagh , Musa Ibrahim
Keywords
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