REPRODUCTIVE SAFETY ASSESSMENT OF A POLYHERBAL ANTIHYPERTENSIVE MIXTURE IN GHANA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Medications designed to treat symptoms and cure chronic diseases can also cause unanticipated problems with the reproductive system; even in therapeutic doses. This study was therefore conducted on a commonly used polyherbal antihypertensive product on the Ghanaian market to ascertain its reproductive toxicity in both females and males. Couple-mediated and male-specific toxicities (endpoints) that measure characteristics for successful sexual performance and procreation were investigated in ICR mice. Data obtained indicated that the product did not have any negative effect on mating behavior and fertility in both female and male mice. It did not affect gestation; neither did it have detrimental effect on litter number and litter weight, live birth and weaning index. The product also did not affect caudal epididymis and testis weight. Spermatozoa concentrations, spermatozoa motility and viability after semen analysis were also not affected after semen analysis. The endpoints that measure characteristics for successful sexual performance and procreation were not adversely affected with the use of the product under study, therefore, as far as reproductive toxicity is concerned, the polyherbal antihypertensive mixture is safe to use within limits of the doses administered in this study.
Authors and Affiliations
George Koffuor , Eric Woode , Kwesi Mensah , Anthony Oppong-Gyebi
Keywords
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