Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol
Journal Title: Journal of Clinical Medical Research - Year 2020, Vol 1, Issue 2
Abstract
Paracetamol is that the one amongst the foremost broadly speaking NSAIDS used as antipyretic and analgesic drug within the world. However, still its Mechanism of Action (MOA) is not fully recognize. The potential Mechanism of Action (MOA) of paracetamol as its antipyretic and analgesic impact was thought multiple pathway. Some action relies on the inhibition of the Cyclooxygenases (COX enzyme) and a lot of recently study show that it additionally acts on serotonergic pathways (5HT pathway). A brand new metabolic pathway of paracetamol (as a prodrug) is come back to grasp, involving the generation of a lively matter, AM404 (N- 4Hydroxyphenyl-5Z, 8Z, 11Z, 14Z-eicosatetraenamide), by the (FAAH) carboxylic acid organic compound hydrolase protein within the brain, was recently known. This review describes the theoretical knowledge that show the affiliation of this metabolic pathway within the analgesic & antipyretic action of acetaminophen (PCM) and its relationship with the enzyme protein (COX) and (5-HT) serotonergic systems. It additionally shows that the new systems (cannabinoid and vanilloid systems) and targets as well as the atomic number 20 channel receptor (Cav3.2), play an important role within the flightless bird of paracetamol.
Authors and Affiliations
Sarbjeet Singh, Mandeep Kaur
Keywords
Related Articles
- EP ID EP698953
- DOI http://dx.doi.org/10.46889/JCMR.2020.1201
- Views 118
- Downloads 0
Assessment of Some Micronutrients and Vitamins of HIV Positive Patients in South-South Nigeria
Background: Human Immunodeficiency Virus (HIV) infection continues to be a serious health issue in most parts of the world, with a global prevalence of 0.7% among adults, the majority being in developing countries with l...
Artificial Intelligence in Post Pandemic
In 1997, artificial intelligence burst onto the scene with news that made the front pages of newspapers. It was reported that the DEEP BLUE robot had defeated the world chess champion Gary Kasparov. This event shook up t...
The Study of Relationship between Plasma Fibrinogen Level and the Macrovascular Complications in Type 2 Diabetes Mellitus patients in a Tertiary Health Care Centre in Eastern India
Introduction: The macrovascular complications in patients of Type 2 Diabetes Mellitus (T2DM) are an expression of the generalized atherosclerotic process affecting the blood vessels of the body. Studies have revealed car...
Gall bladder Tuberculosis Mimicking Malignancy: An Unusual Case Report with Review of Literature
Isolated gall bladder tuberculosis is a highly rare disease entity. It may be associated with other intra-abdomen tuberculosis, which may involve the gallbladder via the lymphatics or bloodstream pathway. We intend to...
Neurodevelopmental Outcome in Infants of Gestational Diabetic Mother in a Tertiary Care Hospital, Dhaka, Bangladesh
Background: Diabetes Mellitus (DM) is one of the most common metabolic complications of pregnancy, with negative influences on maternal and fetal health. Infants of Diabetic Mothers (IDMs) are prone to develop both early...