Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol
Journal Title: Journal of Clinical Medical Research - Year 2020, Vol 1, Issue 2
Abstract
Paracetamol is that the one amongst the foremost broadly speaking NSAIDS used as antipyretic and analgesic drug within the world. However, still its Mechanism of Action (MOA) is not fully recognize. The potential Mechanism of Action (MOA) of paracetamol as its antipyretic and analgesic impact was thought multiple pathway. Some action relies on the inhibition of the Cyclooxygenases (COX enzyme) and a lot of recently study show that it additionally acts on serotonergic pathways (5HT pathway). A brand new metabolic pathway of paracetamol (as a prodrug) is come back to grasp, involving the generation of a lively matter, AM404 (N- 4Hydroxyphenyl-5Z, 8Z, 11Z, 14Z-eicosatetraenamide), by the (FAAH) carboxylic acid organic compound hydrolase protein within the brain, was recently known. This review describes the theoretical knowledge that show the affiliation of this metabolic pathway within the analgesic & antipyretic action of acetaminophen (PCM) and its relationship with the enzyme protein (COX) and (5-HT) serotonergic systems. It additionally shows that the new systems (cannabinoid and vanilloid systems) and targets as well as the atomic number 20 channel receptor (Cav3.2), play an important role within the flightless bird of paracetamol.
Authors and Affiliations
Sarbjeet Singh, Mandeep Kaur
Keywords
Related Articles
- EP ID EP698953
- DOI http://dx.doi.org/10.46889/JCMR.2020.1201
- Views 120
- Downloads 0
Re-Formation: Reactionary or Reparative Dentin
Dentin (s) are complex structures including in the crown, the formation of the mantle dentin mostly atubular, and circumpulpal dentin, crossed along its entire length by 180,000-240,000 tubules per mm2. In the root, two...
Comparative Studies of the Tongue of Postnatal (Lactating), Young and Adult Between Two Species of Mammalian Animals of Different Feeding Habit Rattus Rattus and Orcytolagus Cuniculus
Background: The study of tongue of mammals is important because the different species of animals with different feeding, so the present study was attended to observe the relation between various feeding and the morpholog...
Real Time Health Monitoring For Palliative Patients through MSE-WBAN Architecture
The mobile-Health (mHEALTH) is the application of digital technology in health care services to bring the health care services into a digital format and to introduce the culture of digitalization in health-related matt...
To Mask or Not to Mask Correctly: An Empirical Look at Public Masking Behavior
Introduction: Mask usage was mandated by public health authorities globally to decrease the spread of COVID-19. These recommendations were based on data showing that N95 masks and possibly surgical masks, when worn tight...
Acute Polyradiculoneuritis in A COVID-19 Patient Gamifying Exercise in the Elderly
It was found that the infection with Severe Acute Respiratory Syndrome Coronavirus 2 may lead to the appearance of several complications, including neurological ones. The aim of this article is to present the first and o...