Mechanisms of methamphetamine-induced dopaminergic neurotoxicity

Journal Title: The AAPS Journal - Year 2006, Vol 8, Issue 2

Abstract

Methamphetamine (METH) is a powerful stimulant of abuse with potent addictive and neurotoxic properties. More than 2.5 decades ago, METH-induced damage to dopaminergic neurons was described. Since then, numerous advancements have been made in the search for the underlying mechanisms whereby METH causes these persistent dopaminergic deficits. Although our understanding of these mechanisms remains incomplete, combinations of various complex processes have been described around a central theme involving reactive species, such as reactive oxygen and/or nitrogen species (ROS and RNS, respectively). For example, METH-induced hyperthermia, aberrant dopamine (DA), or glutamate transmission; or mitochondrial disruption leads to the generation of reactive species with neurotoxic consequences. This review will describe the current understanding of how high-dose METH administration leads to the production of these toxic reactive species and consequent permanent dopaminergic deficits.

Authors and Affiliations

Evan L. Riddle, Annette E. Fleckenstein, Glen R. Hanson

Keywords

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  • EP ID EP681795
  • DOI  10.1007/BF02854914
  • Views 73
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How To Cite

Evan L. Riddle, Annette E. Fleckenstein, Glen R. Hanson (2006). Mechanisms of methamphetamine-induced dopaminergic neurotoxicity. The AAPS Journal, 8(2), -. https://europub.co.uk/articles/-A-681795