MECHANISTIC EFFECT OF DIETARY COMPONENTS IN MANAGING OBESITY
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Life style related diseases like obesity, diabetes and cancer threaten the health worldwide. Attention has been focused recently on the study of relation between the food/plant derived components and their effect on target gene to identify the novel pathway involved in the disorder and their future use as therapeutics. Obesity is a complex multifactorial disorder associated with many health problems including hyperlipidemia, hypertension, type2 diabetes, coronary heart disease and cancer. Obesity is caused by the imbalance between the calories intake and the expenditure that lead to the pathological growth and deposition of adipocytes. Adipocytes play a central role in regulating the adipose mass. In obesity, the increased mass of adipose tissue leads to the adipose tissue hyperplasia, triggering the transformation of preadipocytes to adipocytes. The programmed differentiation of preadipocytes to adipocytes is accompanied by increase in the expression of various transcription factors and adipocyte specific-gene. This review highlights on the studies to explain the mechanism of action of various dietary components interacting with proteins involved in adipogenesis.
Authors and Affiliations
Dr. Sneharani A. H.
Keywords
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