Medical Method of Second Trimester Abortion: Mifepristone Plus Misoprostol vs Misoprostol Alone
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Second trimester abortions constitute 10– 15% of all induced abortions worldwide but are responsible for two-thirds of all major abortion-related complications. Second trimester abortion can be done by surgical or medical method. Surgical abortion mainly dilatation and evacuation is responsible for majority of complications like haemorrhage, perforation and infection. Medical abortion has the potential to reduce these complications. For second trimester abortion misoprostol is widely used. Mifepristone is antiprogesterone and as we know progesterone is the key hormone in maintaining pregnancy, so addition of mifepristone with misoprostol can increase its effectiveness. Material and Methods: This is a case control study. A total of 120 patients were selected between gestational ages 13 weeks to 20 weeks with various indications for termination of pregnancy. They were divides into two groups (case and control). Case (Group A): Women who received Mifepristone and Misoprostol. Control (Group B): Women who received Misoprostol alone. Result: In Group A maximum dose of misoprost required in both nulliparous and parous women were 3 while in Group B 13 patients required 4 doses and 2 patients required 5 doses. In group A induction abortion interval was less than 6 hours in 42 women while in group B only 14 women aborted in less than 6 hours. There was no significant difference in adverse effects observed in both groups. Conclusion: Combining mifepristone with misoprostol significantly increases the effectiveness of medical method of second trimester abortion.
Authors and Affiliations
Bijeta A, Neelam Nalini
Keywords
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