Medicinal Activity of Avicenniaofficinalis: Evaluation of Phytochemical and Pharmacological Properties
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 9
Abstract
Abstract: Antioxidant activity and total phenolic content of EtOH extract of Avicenniaofficinalis leaves were determined by DPPH free radical scavenging assay and Folin-Ciocalteau assay, respectively. IC50 value was 160.92 µg/ml in DPPH assay and total phenolic content was 208.57mg GAE/100 g of dry powder. The sample produced 18.75% and 51.88% (P<0.01) writhing inhibition at the doses of 250 and 500 mg/kg body weight, respectively, in acetic acid-induced writhing model using Swiss-albino mice. It showed accountable antibacterial activity against Escherichia coli and Salmonella typhi in disc diffusion assay. MIC was found to be as 62.5 μg/ml against E. coliand 125 μg/mlagainst S. typhi. In brine shrimp lethality bioassay LC50 value was found 131.203 µg/ml. Preliminary phytochemical screening confirmed the presence of important phytochemicals like carbohydrate, reducing sugar, combined reducing sugar, glycosides, tannins, alkaloids, proteins, terpenoids and flavonoids which may be responsible for antioxidant, analgesic, cytotoxic and accountable antibacterial activity. Keywords: Antioxidant; Total phenolic content; Analgesic; Antibacterial; Cytotoxic activity
Authors and Affiliations
Shamsunnahar Khushi, Md. Mahadhi Hasan, A. S. M. Monjur-Al-Hossain, Md. Lokman Hossain, Samir Kumar Sadhu
Keywords
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