Melatonin and thermal stress regulate differential expression of heat shock proteins and melatonin receptors in spleen of mice
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 1
Abstract
Cellular defence by expression of heat shock proteins (Hsps) against stress stimulation is the most universal phenomenon in stress physiology. Melatonin is well known as an anti-stress molecule possessing hypothermic effects. It protects cells and tissues in stressed conditions. Individually, Hsp70 and melatonin shows its functional ability in stressed organisms as well as in immune functions. The aim of the present study was to determine the interaction of melatonin receptors (MT1/MT2) in exogenous melatonin modulated expression of heat shock proteins (Hsp70/Hsc70) in spleen of thermally stressed male mice. Results of the study showed thermal stress significantly increased the Hsp70/Hsc70 and melatonin receptor MT2 expression in spleen of mice. The administration of melatonin significantly increased Hsp70 expression, but decreased Hsc70 expression. Both MT1/MT2 receptor expressions increased after melatonin treatment, whereas thermal stress to melatonin treated mice showed decrease in MT1/MT2 receptor expression than the only melatonin treated mice. MT2 receptor is responding in all experimental conditions corresponding to changes in Hsp70 protein expression. Therefore, the present study might suggest that MT2 receptor is interacting in coordination of melatonin mediated heat shock proteins expression in mice spleen after thermally stressed conditions.
Authors and Affiliations
Samik Acharjee| Molecular Endocrinology Research Laboratory, Department of Zoology, Tripura University, Suryamaninagar – 799022, Tripura (W), India., Shiv Shankar Singh| Molecular Endocrinology Research Laboratory, Department of Zoology, Tripura University, Suryamaninagar – 799022, Tripura (W), India.
Keywords
Related Articles
- EP ID EP15236
- DOI -
- Views 326
- Downloads 15
Recent trends and advances in hemophilia – its management and new therapeutic outcomes
Hemophilia unfortunately a less attracted disease for researchers compared to other life threatening diseases. The prevalence of hemophilia is estimated to be about 1:10,000 birth and that of the severe form of the dis...
Melatonin and thermal stress regulate differential expression of heat shock proteins and melatonin receptors in spleen of mice
Cellular defence by expression of heat shock proteins (Hsps) against stress stimulation is the most universal phenomenon in stress physiology. Melatonin is well known as an anti-stress molecule possessing hypothermic e...
The efficacy of polyherbal formulation of Moringa oleifera, Viola odorata, Allium sativum against microbes- synergistic effect
The purpose of our present study is to test antimicrobial and antifungal activity of polyherbal formulations. The testing of the antimicrobial activity on polyhernal formulation was done against gram positive (Staphylo...
Ethnomedicinal plants of Jodhpur District, Rajasthan used in herbal and folk remedies
The Jodhpur district a part of Thar Desert is very rich in medicinal plant wealth. The medicinal plants of this region have great potential to be used in drug and pharmaceutical industries. These herbal plants have bee...
Capparidaceous Medicinal Plants of North-West Rajasthan: Good Sources of Ascorbic Acid
Ascorbic acid contents of roots, shoots and fruits of three selected medicinal plants like Capparis decidua, Cleome gynandra and Cleome viscosa of family Capparidaceae have been analysed. Maximum ascorbic acid contents...