Memory Enhancing Activity of Dendrobium macraei Lindl. in Swiss Albino Mice
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 13, Issue 2
Abstract
Background: Memory is not a single process, but rather a series of interactive processes beginning when we are exposed to new information, which is registered by the brain, encoded, and in the right conditions, stored for later retrieval. Short and long term memory loss may result from deteriorating cerebral mechanisms due to different causes having impact on the quality of life. Memory enhancers can improve thinking, memory, and alertness in people with Alzheimer’s disease or dementia that affect the mind or memory. Objective: In the present study, an attempt has been made to highlight the importance of the plant Dendrobium macraei Lindl. (family- Orchidaceae) in the field of traditional medicines which is traditionally used as memory enhancer. Methods: The present study comprises in vivo memory enhancing activity evaluation in mice using various memory models such as elevated plus maze model and Morris water maze model. Piracetam was used as standard drug. Effects of various extract viz. petroleum ether, chloroform, ethyl acetate, methanol and aqueous extract of D. macraei were evaluated for memory enhancing activity. Results and Conclusion: Amongst all extracts tested, only ethyl acetate and methanol extract of D. macraei showed significant short term and long term memory enhancing activity using elevated plus maze model and Morris water maze model in mice respectively. Ethyl acetate extract (200 mg/kg, p.o.) showed marked significant (P<0.05) effect as compared to methanol extract (200 mg/kg, p.o.) in both the models. Therefore, it would be worthwhile to explore the potential of this plant in the management of dementia.
Authors and Affiliations
Esha Vatsa, Kundan Singh Bora
Keywords
Related Articles
- EP ID EP342151
- DOI 10.9734/BJPR/2016/28090
- Views 117
- Downloads 0
Amelioration Effect of Emblica officinalis Extract on Ovary in Endosulfan Induced Swiss Albino Mice
Background: In the present time use of pesticides has become very common by the farmers for the better yield of crops. Endosulfan, a chlorinated cyclodiene insecticide, is widely and very liberally used in agricultural s...
Uterine Relaxation Potential of Ethanol Leaf Extract of Moringa oleifera Lam. VIA the Muscarinic Receptor Pathway
Aim: The effect of Ethanol Leaf Extract of Moringa oleifera (ELMO) on uterine smooth muscles of non- pregnant female rats was studied in vitro with a view to finding out the mechanism(s) for observed effects. Experientia...
Acute and Sub-acute Oral Toxicity Study of Drepanoalpha® (A Poly-Herbal Formula Used in the Management of Sickle Cell Disease) in Guinea-pigs
Aims: To deepen the toxicological investigation of Drepanoalpha®, a poly-herbal formula used for its antisickling and radical scavenging properties in Congolese traditional medicine. Study Design: To evaluate lethality,...
Anxiolytic, Sedative and Hypothermic Effects of Aqueous Leaf Extract of Vernonia amygdalina Del. (Asteraceae) in Albino Mice
Aims: This study evaluated the anxiolytic, sedative and hypothermic effects of aqueous leaf extract of Vernonia amygdalina in Mice. Study Design: One-factor two control groups experimental design. Place and Duration of...
Plants in Respiratory Disorders I- Anti-asthmatics, A Review
Aim of This Review: Respiratory disorders pose a big threat to life and constitute a major public health problem worldwide. This review is an attempt to bring together some of the common medicinal plants traditionally us...