MEMORY ENHANCING ACTIVITY OF HYDROALCOHOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The present study was to evaluate the effect of Terminalia catappa on cognitive functions and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The extract of Terminalia catappa was administered orally at three doses (100, 200 and 300 mg/kg) for 7 and 14 consecutive days to the respective groups of rats. Piracetam (120 mg/kg) was used as a standard nootropic agent. Learning and memory parameters were evaluated using elevated plus maze (EPM) and passive avoidance. Brain cholinesterase activity was evaluated. It was observed that Terminalia catappa at the above- mentioned doses after 7 and 14 days of administration in the respective groups significantly reversed scopolamine (1 mg/kg i.p.)- induced amnesia, as evidenced by a decrease in the transfer latency in the EPM task and step-down latency in the passive avoidance task. Terminalia catappa reduced the brain ChE activity in rats.
Authors and Affiliations
Ankur Joshi
Keywords
Related Articles
- EP ID EP301800
- DOI -
- Views 69
- Downloads 0
Preliminary phytochemical analysis, antimicrobial and antioxidant activity of Smilax zeylanica L. (Smilacaceae)
Objectives: Smilax zeylanica L. is a large, dioecious, scandent climbing shrub and an important medicinal plant belonging to the family Smilacaceae. The present study evaluates antimicrobial and antioxidant potential of...
PREPARATION, CHARACTERIZATION, AND OPTIMIZATION OF MICROEMULSION FOR TOPICAL DELIVERY OF ITRACONAZOLE
absorption of both lipophilic and hydrophilic medicaments when compared to conventional vehicles (emulsions, pure oils, aqueous solutions). Hence the aim of present investigation is to prepare, characterize and optimize...
POLYMER -LIPID HYBRID NANOPARTICLES FOR BRAIN TARGETING THROUGH INTRANASAL DELIVERY
Brain targeting is a difficult task due to various factors; those factors can restrict the entry of drugs into the brain, in the present study polymer-lipid hybrid nanoparticles were prepared for targeting carbamazepine...
Formulation and evaluation of chitosan containing mucoadhesive buccal patches of metoprolol succinate
Mucoadhesive buccal patches containing metoprolol succinate were prepared using the solvent casting method. Chitosan was used as bioadhesive polymer and different ratios of chitosan to PVP K-30 were used. The patches wer...
AWARENESS ABOUT LIFESTYLE DISEASES AMONGST THE SCHOOL GOING ADOLESCENTS OF DELHI
Objective: This study aims to assess the awareness about lifestyle diseases amongst the school going adolescents of different Gov. Schools of Delhi Material and Methods: An interventional, quasi experimental pre-post d...