肝硬化食管静脉曲张破裂出血危险因素的Meta分析
Journal Title: Di-er Junyi Daxue Xuebao - Year 2007, Vol 28, Issue 8
Abstract
目的:综合分析肝硬化门脉高压症下食管静脉曲张破裂出血的危险因素,为制定相关预防措施提供临床依据。方法：检索1986~2006年国内外针对食管静脉曲张破裂出血危险因素的临床研究,进行Meta分析,计算每个危险因素的优势比值(OR值)及其95%可信区间[95% CI]。结果：共纳入研究的文献19篇,累积病例2 849例(出血组995例,对照组1 854例)。Meta分析提示,肝功评分Child C级、凝血酶原活动度降低、低白蛋白血症、重度食管静脉曲张、红色征阳性、门静脉增宽、脾静脉增宽、血小板减少、白细胞减少、贫血均为食管静脉曲张破裂出血的危险因素；而肝功评分Child A级、轻度食管静脉曲张为食管静脉曲张破裂出血的保护因素；性别、年龄、肝功能评分Child B级、出现腹水、发生肝性脑病、高胆红素血症以及中度食管静脉曲张与曲张静脉破裂出血无显著相关。结论:改善Child C级患者肝功能、恢复正常凝血功能、纠正低白蛋白血症、针对重度曲张静脉预防性内镜下治疗或行预防性断流术以及分流术等有助于降低食管静脉曲张破裂出血的发生率。
Authors and Affiliations
Keywords
Related Articles
- EP ID EP83997
- DOI -
- Views 141
- Downloads 0
Needle-tract bleeding after percutaneous radiofrequency ablation for hepatocellular carcinomas: risk factors,prevention and treatment
Objective:To analyze the risk factors,prevention and treatment of needle-tract bleeding after percutaneous image-guided radiofrequency ablation (PRFA) for hepatocellular carcinomas (HCC).Methods: A total of 1 567 RFA ses...
Retroperitoneal laparoscopic nephropexy: a report of 28 cases
Objective: To discuss the procedure and clinical effect of retroperitoneal laparoscopic nephropexy (RLN).Methods: From August 2001 to June 2006, RLN was performed on 28 female patients aged 2645 years old (mean, 34±2.5...
LC-MS/MS in determination of telmisartan concentration in human plasma
Clinical observation of capecitabine as first-line monotherapy in elderly patients with Ⅱa breast cancer
Objective:To observe the clinical effect and adverse reaction of capecitabine as first-line monotherapy in elderly patients with stage Ⅱa breast cancer.Methods: From June 2002 to June 2005,71 elderly patients with stage...
Construction and identification of recombinant adenovirus containing wild-type human PKGⅠα gene
Objective:To clone human PKGⅠα gene and construct a recombinant adenovirus vector containing wild-type PKGⅠα.Methods: RT-PCR was used to amplify the full-length PKGⅠα gene from human pulmonary arterial smooth muscle.Afte...