Metabolic profile and morpho-functional state of the liver in rats with glutamate-induced obesity
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 4
Abstract
The aim of our study was to investigate effects of monosodium glutamate (MSG) neonatal treatment on metabolic profile and liver morpho-functional state in rats at 16-weeks of age. Our study confirms previously reported data that neonatal treatment with MSG, administered by subcutaneous injection, is able to induce obesity without hyperphagia, which is diagnosed by high Lee index and characterized by small corporal weight and naso-anal length. It was established that MSG neonatal treatment induced metabolic changes at 16 weeks of age, which manifested as disproportional laying of fat deposits with the development of visceral obesity. The level of adiponectin was decreased after MSG neonatal treatment. Also, we showed development of dyslipidemia and non-alcoholic fatty liver disease and impairment sensitivity of peripheral tissue to insulin.
Authors and Affiliations
Maryana Kondro, Galyna Mykhalchyshyn, Petro Bodnar, Nazarii Kobyliak, Tetyana Falalyeyeva
Keywords
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