Metabolic syndrome and the risk of chronic kidney disease
Journal Title: Нирки - Year 2017, Vol 6, Issue 2
Abstract
Metabolic syndrome (MS) is a combination of a disorder of carbohydrate metabolism, abdominal obesity, dyslipidemia and arterial hypertension. Studies show that there is a close relationship between MS and chronic kidney disease (CKD). Patients with MS have a 2.5-fold higher risk of CKD. Factors of CKD development in the metabolic syndrome are an increased level of insulin and insulin resistance, active forms of oxygen, inflammatory mediators, biologically active substances, hormones, inflammatory cytokines, an increase in the activity of coagulation factors, inhibition of the fibrinolytic system. Pathological abnormalities in the kidneys in patients with MS are manifested by microvascular tubular atrophy, interstitial fibrosis and global or segmental sclerosis. Microalbumin is an early marker for MS.
Authors and Affiliations
O. O. Melnyk
Endothelial dysfunction in the pathogenesis of diabetic kidney disease
The article deals with the integrated characteristics of hyperglycemia role in the pathogenesis of vascular complications of diabetes mellitus. The article analyzes the modern data on the mechanisms of development and pr...
Chronic Kidney Disease and Ecology
The review of literature presented the relationship between the development of chronic kidney disease with the ecological state of areas of residence of patients, the impact of xenobiotics (inorganic and organic chemical...
Antibiotic resistance and vaccination in patients with urinary tract infection
Limited in experience of using uroantiseptics, even those manufactured in European countries, such as Furamag and Macmiror, excessive use of antibiotics, which causes antibiotic resistance in the EU countries and form re...
Influence of Aflazin® on the Adhesive Properties of Microorganisms — Pathogens of Catheter-Related Infections
The influence of Aflazin® (UTIRose™) and separately its combination with levofloxacin on the adhesive properties of opportunistic pathogens has been studied. It is found that addition of the active substance of Aflazin®...
The use of diuretics in heart failure with congestion — a position statement from the Heart Failure Association of the European Society of Cardiology
The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving...