Metallothionein and manganese concentrations in brain tumors
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
Metallothioneins (MT) take part in the homeostasis of the metals which are necessary for the proper metabolism and they also take part in the detoxication of toxic metals from the tissues. They also protect the tissue from the effects of reactive oxygen species, radiation, electrophilic pharmacologic agents used in the cancer therapy and from mutagens. Manganese (Mn) – essential microelement – seems to be very important during development. Mn takes a part as cofactor of the enzymes regulating the metabolism. This microelement also participates in the reduction-oxidation reactions. An example of such reaction is the superoxide dismutase (MnSOD) activity with manganese as enzyme component. It is thought that manganese and manganese superoxide dismutase play an important role in the differentiating cells. The aim of this work was to determine the level of metallothionein and manganese in the brain neoplastic tissues, astrocytoma G-2 and malignant gliomas (astrocytoma G-4). The experimental materials were primary glial the brain neoplastic tissues resected during neurosurgical procedures. The level of the metallothionein was determined by the cadmium-hemoglobin affinity assay using the cadmium isotope ([sup] 109 [/sup]Cd), and the concentration of manganese was determined by atomic absorption spectrometry. The concentration of metallothionein and manganese was found to be higher in the astrocytoma G-4 (glioblastoma multiforme) patients. Negative correlation between the concentration of metallothionein and manganese ions was found in astrocytoma G-2 cells.
Authors and Affiliations
Bolesław Floriańczyk, Robert Kaczmarczyk, Jacek Osuchowski, Tomasz Trojanowski
Keywords
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